Signal transduction mechanisms through Fc gamma receptors on the mouse macrophage surface.
Signal transduction mechanisms through Fc gamma receptors on the mouse macrophage surface.
复制标题
通过小鼠巨噬细胞表面 Fc γ 受体的信号转导机制。
DOI：
10.1096/fasebj.5.2.1706281
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Suzuki,T
中科院分区：
文献类型：
--
作者：
Suzuki,T
Mouse macrophages and macrophage cell lines such as P388D1or J774 carry at least two distinct Fcγ receptors (FcγR): one specific for the Fc portion of IgG2a (Fcγ2aR, also classified as FcγRI) and another for IgG2b (Fcγ2bR, also classified as FcγRIIβ). These FcγRs should transmit, upon binding of an appropriate ligand, a specific signal that leads to the regulation of macrophage functions, as the interaction of immune complex with cell surface receptor has been shown to lead to suppression of the humoral immune response or B cell differentiation, to the destruction of target cells by antibody‐dependent cell‐mediated cytotoxicity, to activation of arachidonic acid metabolic cascade, to the phagocytosis of opsonized particles, or to the generation of superoxide anion. In this review, we first describe evidence that Fcγ2aR and Fcγ2bR are associated with casein kinase II and phospholipase A2activity, respectively. We will then discuss a potential role for these enzymatic activities in signal transduction pathways that leads to the activation of the arachidonic acid metabolic cascade and adenylate cyclase, to the regulation of phagocytosis, and to the suppression of interferon‐γ action to induce la antigens.—Suzuki, T. Signal transduction mechanisms through Fcγ receptors on the mouse macrophage surface.FASEB J.5: 187–193; 1991.
