Impaired renal function is associated with markers of endothelial dysfunction and increased inflammatory activity
Impaired renal function is associated with markers of endothelial dysfunction and increased inflammatory activity
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DOI：
10.1093/ndt/gfg080
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发表时间：
2003-05-01
影响因子：
6.1
通讯作者：
Stehouwer, CDA
中科院分区：
文献类型：
--
作者：
Stam, F;van Guldener, C;Stehouwer, CDA
背景。终末期肾病（ESRD）患者以及轻度肾功能不全患者发生心血管疾病的风险增加，这不能完全归因于传统的危险因素。内皮功能障碍和慢性炎症活动是动脉粥样硬化发生的两个重要现象，可在ESRD中发现。目前，内皮功能障碍和慢性炎症活动是否与透析前肾功能有关尚不清楚。在一项横断面单中心研究中，四组20名受试者的肾功能从正常计算的肌酐清除率（> 90 ml/min）到透析前状态(
Background. Patients with end-stage renal disease (ESRD) as well as those with mild renal insufficiency are at increased risk for the development of cardiovascular disease, which cannot be attributed entirely to traditional risk factors. Endothelial dysfunction and chronic inflammatory activity, two important phenomena in atherogenesis, can be found in ESRD. At present, it is unclear whether endothelial dysfunction and chronic inflammatory activity are related to renal function in the pre-dialysis stage.Methods. In a cross-sectional, single-centre study, four groups of 20 subjects with renal function ranging from a normal, calculated creatinine clearance (> 90 ml/min) to a pre-dialysis situation (