Chondroblastoma: clinicopathological analyses of 307 cases from a single institution in China and the diagnostic value of the H3F3 K36M mutant antibody
Chondroblastoma: clinicopathological analyses of 307 cases from a single institution in China and the diagnostic value of the H3F3 K36M mutant antibody
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DOI：
10.1136/jcp-2022-208630
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Zhiyan Liu
中科院分区：
文献类型：
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作者：
Qianqian Zhao;Juan Tang;Yanli Luo;Jin Huang;Dingjun Hu;Jinyu Zhu;Ting Jiang;Huizhen Zhang;Zhiyan Liu
AimsTo elucidate the clinicopathological features and the diagnostic value of mutation specific antibody H3F3 K36M of chondroblastoma (CB) in China.MethodsClinicopathological profiles were retrieved, and immunohistochemistry was performed on 185 CB specimens and the control group.ResultsOur series included 307 patients with a mean age of 22.1 years. Long tubular bones (63.8%, 196/307) were most commonly involved, followed by short bones of the hands and feet (22.1%, 68/307), sesamoid bones (8.1%, 25/307), flat bones and irregular bones (5.9%, 18/307). The most commonly involved site was the proximal femur, followed by distal femur, proximal humerus and calcaneus. The average age in the long bones group (20.3 years) was significantly younger than the short bones group (24.9 years) (pConclusionsCB usually involves the long tubular bones in younger age group. H3F3 K36M can identify K36M mutation with 100% specificity and 100% sensitivity in non-decalcified and EDTA decalcified samples, more than 80% sensitivity in HCl decalcified samples. Virtually, all CBs harbour an H3K36M mutation.
