TEMPORAL-LOBE ABNORMALITIES IN PANIC DISORDER - AN MRI STUDY
TEMPORAL-LOBE ABNORMALITIES IN PANIC DISORDER - AN MRI STUDY
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DOI：
10.1016/0006-3223(90)90004-l
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发表时间：
1990-02-01
影响因子：
10.6
通讯作者：
ELIE, R
中科院分区：
文献类型：
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作者：
FONTAINE, R;BRETON, G;ELIE, R
Braim 绘图研究表明，惊恐障碍 (PD) 患者的脑血容量和耗氧量发生异常变化，或其他神经生理学异常。由于他们的有趣报告，我们决定使用磁共振成像 (MRI) 评估 PD 患者的神经解剖学方面。我们纳入了 31 例根据 DSM-III 标准诊断为 PD 的连续病例和 20 例对照。所有受试者都必须是右利手且年龄在 20 至 40 岁之间。 应用通常的排除标准。我们使用 1.5 特斯拉运行的通用电气 Signa 机器进行了 MRI 测试。每个患者获得了 100 多张图像，重点是评估颞叶。患者和对照组之间的年龄、性别或体重没有显着差异。我们发现，与对照组 (10%) 相比，PD 患者 (40%) 的异常数量在统计学上显着更高。最引人注目的发现是颞叶的局灶性异常：信号活动异常的区域和颞叶的不对称萎缩大多发生在右侧。这些结果涉及边缘系统，并可能被证明与恐慌和恐惧症特别相关。然而，我们的研究结果的意义仍然未知且具有挑战性。为了更好地了解这种疾病，需要对 PD 进行进一步的 MRI 研究。
Braim mapping studies have shown abnormal changes in cerebral blood volume and oxygen consumption, or other neurophysiological abnormalities, in panic disorder (PD) patients. Because of their intriguing reports, we decided to assess the neuroanatomical aspects of patients with PD using magnetic resonance imaging (MRI). We included 31 consecutive cases with a diagnosi of PD according to the DSM-III criteria, and 20 controls. All subjects had to be right-handed and between 20 and 40 years of age. The usual exclusion criteria were applied. We carried out the MRI tests with a General Electric Signa Machine operating at 1.5 Tesla. Over 100 images were obtained per patient with an emphasis on assessing temporal lobe. There were no significant differences in age, gender, or weight between the patients and controls. We found a statistically significant higher number of abnormalities in PD patients (40%), as compared with the controls (10%). The most striking findings were focal abnormalities in the temporal lobes: areas of abnormal signal activity, and asymmetric atrophy of the temporal lobe occurred mostly on the right side. These results implicated the limbic system and may prove to be of particular relevance in panic and phobic disorders. However, the significance of our findings remains unknown and challenging. Further MRI studies in PD will be required for a better understanding of the illness.