Pathology of graft-versus-host disease in the gastrointestinal tract
Pathology of graft-versus-host disease in the gastrointestinal tract
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DOI：
10.1016/j.humpath.2009.04.001
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发表时间：
2009-07-01
期刊：
影响因子：
3.3
通讯作者：
Jagasia, Madan
中科院分区：
文献类型：
--
作者：
Washington, Kay;Jagasia, Madan
移植物抗宿主病（GVHD）是造血干细胞移植的常见并发症，是一种临床综合征，需要综合临床、实验室和组织病理学结果进行诊断。胃肠道（GI）通常受到影响，病理学家必须识别GI粘膜活检中的细微形态学改变，以进行诊断并排除GI功能障碍的其他原因，如巨细胞病毒感染和药物作用。这篇综述总结了GVHD在胃肠道的组织病理学特征，并概述了最近的建议，报告胃肠道活检可疑GVHD。(C)2009 Elsevier Inc. All rights reserved.
Graft-versus-host disease (GVHD), a common complication of hematopoietic stem cell transplantation, is a clinical syndrome that requires synthesis of clinical, laboratory, and histopathologic findings for diagnosis. The gastrointestinal (GI) tract is commonly affected, and pathologists must recognize subtle morphologic alterations in GI mucosal biopsies to make the diagnosis and to rule out other causes of GI dysfunction such as cytomegalovirus infection and drug effects. This review summarizes the histopathologic features of GVHD in the GI tract and outlines recent recommendations for reporting of GI biopsies with suspected GVHD. (C) 2009 Elsevier Inc. All rights reserved.