Prevalence of insulin resistance in the polycystic ovary syndrome using the homeostasis model assessment
Prevalence of insulin resistance in the polycystic ovary syndrome using the homeostasis model assessment
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DOI：
10.1016/j.fertnstert.2004.11.070
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发表时间：
2005-05-01
影响因子：
6.7
通讯作者：
Azziz, R
中科院分区：
文献类型：
--
作者：
DeUgarte, CM;Bartolucci, AA;Azziz, R
目的：了解多囊卵巢综合征（PCOS）患者胰岛素抵抗（IR）的患病率。设计：前瞻性，病例对照。地点：大学医疗中心。患者：271名多囊卵巢综合征患者和260名痛经、无多毛的对照组女性。干预措施：病史、体格检查和血液取样。主要结局指标：总T、游离T、DHEAS、性激素结合球蛋白、空腹血糖和胰岛素水平；稳态模型IR评估值（HOMA-IR）和β细胞功能百分比（HOMA-% β细胞）。结果：除了空腹血糖外，PCOS患者和对照组在所有研究参数上都有显著差异。由于HOMA- ir和HOMA-% β细胞值与种族、年龄和体重指数有不同的相关性，因此对这些共同发起人的HOMA- ir和HOMA-% β细胞值进行了调整。调整后，64.4%的PCOS患者有胰岛素抵抗，2.6%的PCOS患者有p细胞功能障碍。与无IR的PCOS患者（n = 96）相比，IR患者（n = 174）更肥胖，p细胞功能更高。结论：经调整后，经HOMA-IR测量，PCOS患者IR患病率为64%。IR患者的临床影响更大。虽然IR是PCOS中常见的异常，但它似乎并不是一个普遍的特征。(c) 2005年，美国生殖医学学会。)
Objective: To determine the prevalence of insulin resistance (IR) in a large population of patients with the polycystic ovary syndrome (PCOS).Design: Prospective, case-control.Setting: University medical center.Patient(s): Two hundred seventy-one PCOS patients and 260 eumenorrheic, non-hirsute, control women.Intevention(s): History and physical examination and blood sampling.Main Outcome Measure(s): Total T, free T, DHEAS, sex hormone-binding globulin, and fasting glucose and insulin levels; homeostatic model assessment values for IR (HOMA-IR) and percent beta-cell function (HOMA-%beta-cell).Result(s): Patients with PCOS and controls differed significantly in all parameters studied, except fasting glucose. Because the HOMA-IR and HOMA-%beta-cell values were variably associated with race, age, and body mass index, the HOMA-IR and HOMA-%beta-cell values were then adjusted for these cofounders. After adjustment, 64.4% of PCOS patients were noted to be insulin resistant, and 2.6% had P-cell dysfunction. Compared with PCOS patients without IR (n = 96), patients with IR (n = 174) were more obese and had higher P-cell function.Conclusion(s): In patients with PCOS, the prevalence of IR was 64% according to the HOMA-IR measurement, after adjustment. Patients with IR were more clinically affected. Although IR is a common abnormality in PCOS, it does not seem to be a universal feature. ((c) 2005 by American Society for Reproductive Medicine.)