Antineoplastic Actions of Cinnamic Acids and Their Dimers in Breast Cancer Cells: A Comparative Study
Antineoplastic Actions of Cinnamic Acids and Their Dimers in Breast Cancer Cells: A Comparative Study
复制标题
DOI：
10.21873/anticanres.12749
复制
发表时间：
2018-08-01
影响因子：
2
通讯作者：
Chandra, Surabhi
中科院分区：
文献类型：
--
作者：
Hunke, Megan;Martinez, Wuilian;Chandra, Surabhi
背景/目的：乳腺癌是美国癌症相关死亡的第二大原因，因此需要不断研究副作用最小的药物。这项研究的目的是确定某些肉桂酸二聚体(CADS)对乳腺癌细胞的细胞毒性是否高于对非肿瘤细胞的毒性。材料和方法：由于这些二聚体具有复杂的立体化学结构，到目前为止，这些二聚体还没有被研究过；利用空穴和介导的光二聚化(CMP)方法制备了几种CADS，并对其进行了细胞毒性、细胞凋亡和细胞周期抑制测试。结果：阿魏酸二聚体、3-氟-CAD和3，4-二氟-CAD等CAD比它们的母体单体具有更强的细胞毒性。其中最有效的化合物3-氟-CAD可引起癌细胞的凋亡和‘S’期细胞周期停滞。结论：本研究为开发一类新的抗肿瘤化合物提供了一条研究途径，该化合物可以用一种简单、经济的方法合成。
Background/Aim: Breast cancer is the second leading cause of cancer-related deaths in US, which necessitates constant research for medications with minimal adverse effects. The aim of the study was to determine if certain cinnamic acid dimers (CADs) exhibit higher cytotoxicity in breast cancer cells than against nontumorigenic cells. Materials and Methods: These dimers have not been explored, so far, due to their complex stereochemistry; cavitand-mediated photodimerization (CMP) method was used to produce several CADs, which were tested for cytotoxicity, apoptosis and cell cycle inhibition. Results: CADs such as ferulic acid dimer, 3-fluoro CAD, and 3, 4-difluoro CAD, were found to be more cytotoxic than their parent monomers. The most potent compound, 3-fluoro CAD caused apoptosis and 'S' phase cell cycle arrest in cancer cells. Conclusion: This study indicates an avenue for research for developing a novel class of antineoplastic compounds that can be synthesized using an easy, economical method.