Extracellular pH and P-31 magnetic resonance spectroscopic variables are related to outcome in canine soft tissue sarcomas treated with thermoradiotherapy
Extracellular pH and P-31 magnetic resonance spectroscopic variables are related to outcome in canine soft tissue sarcomas treated with thermoradiotherapy
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DOI：
10.1158/1078-0432.ccr-05-2669
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发表时间：
2006-10-01
影响因子：
11.5
通讯作者：
Dewhirst, Mark W.
中科院分区：
文献类型：
--
作者：
Lora-Michiels, Michael;Yu, Daohai;Dewhirst, Mark W.
目的：目的是测试肿瘤pH值和P-31磁共振波谱终点是否与治疗结果在宠物犬自发性软组织肉瘤治疗thermoradiotherapy.Experimental Design：42只狗与可评估的P-31磁共振波谱终点和pH值数据被纳入本研究。肿瘤变量结果：39只犬中，pHe是无转移生存期（MFS）的预测因子，其风险比为：（HR，0.29; P = 0.005）和总生存期（OS）（HR，0.36; P = 0.013）。肿瘤体积（>19 cm（3））与MFS（HR，2.14; P = 0.04）、局部失败时间（HR，3.4; P = 0.025）和OS（HR，2.27; P = 0.03）相关。T-2或细胞内pH值与临床结局之间无相关性。肿瘤分级（高与低/中等）和磷酸二酯/β ATP比值被确定为MFS的显著预测因子，分别为（HR，2.66; P = 0.009）和（HR，0.75; P = 0.027），并分别为OS的预测因子（HR，2.66; P = 0.009）和（HR，0.76; P = 0.03）。磷酸二酯/磷酸肌酐比值预测局部衰竭时间（HR，1.24; P = 0.017）。结论：pHe可预测犬自发性肉瘤的转移和OS。据我们所知，这是第一次证明p He可预测临床结果。结果表明，应考虑进行额外的研究来评估该变量的预后意义。与膜代谢相关的磷脂共振与临床结果相关，证实了最近在热放疗治疗软组织肉瘤的人类患者中报告的结果。
Purpose: The objective was to test whether tumor pH and P-31 magnetic resonance spectroscopic end points were related to treatment outcome in pet canine patients with spontaneous soft tissue sarcomas treated with thermoradiotherapy.Experimental Design: Forty-two dogs with evaluable P-31 magnetic resonance spectroscopic end points and pH data were included in this study. Tumor variables (grade and volume), extracellular pH (pHe),T-2 relaxation times, intracellular pH, and selected phosphometabolite ratios were examined for correlation with clinical outcome.Results: From 39 dogs, pHe was a predictor of metastasis-free survival (MFS), with hazard ratio (HR, 0.29; P = 0.005) and overall survival (OS) with (HR, 0.36; P = 0,013). Tumor volume (>19 cm(3)) was related to MFS (HR, 2.14; P = 0.04), time to local failure (HR, 3.4; P = 0.025), and OS (HR, 2.27; P = 0.03). There was no association between T-2 or intracellular pH and clinical outcome. Tumor grade (high versus low/intermediate) and phosphodiester/beta ATP ratio were identified as significant predictors for MFS, with (HR, 2.66; P = 0.009) and (HR, 0.75; P = 0.027), respectively, and as predictors of OS with (HR, 2.66; P = 0.009) and (HR, 0.76; P = 0.03), respectively. The phosphodiester/phosphocreatinine ratio predicted time to local failure (HR, 1.24; P = 0.017).Conclusions: pHe was predictive of metastasis and OS in canine spontaneous sarcomas. To our knowledge, this is the first time that p He has been shown to be predictive of clinical outcome. The results suggest that additional studies should be considered evaluating the prognostic significance of this variable. Phospholipid resonances, related to membrane metabolism, were related to clinical outcome, confirming recent results reported in human patients with soft tissue sarcomas treated with thermo radiotherapy.