Phospholipase A Activation Following Extracorporeal Circulation and its Blockade by Procaine
Phospholipase A Activation Following Extracorporeal Circulation and its Blockade by Procaine
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体外循环后磷脂酶 A 的激活及其被普鲁卡因的阻断
DOI：
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
B. Rüstow
中科院分区：
文献类型：
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作者：
D. Olthoff;D. Kunze;B. Rüstow
本文报道了体外循环手术中血浆磷脂酶A活性的变化。在肝素应用后初始增加后，持续升高直至灌注结束，并在灌注结束和鱼精蛋白应用后30分钟降低至正常值。脯氨酸适用于抑制磷脂酶A活性的增加。按照在体外测定的有效剂量为1 mmol/ml，相应的浓度达到了1.5-2 mg/kg/min的输注速率。在第二个系列的调查中，一个显着较小的磷脂酶A的激活过程中的灌注是通过添加普鲁卡因检测。
The phospholipase A activity of human plasma was investigated in the course of operations with the aid of extracorporeal circulation. After an initial increase following heparin application, there is a continuous rise up to the end of perfusion and a decrease to normal values 30 minutes after the end of perfusion and the application of protamine. Procaine is suitable for the inhibition of the increased phospholipase A activity. In accordance with in vitro determinations of an effective dose of 1 mmol/ml, corresponding concentrations were attained with an infusion rate of 1.5-2 mg/kg/min. In a second series of investigations, a significantly smaller phospholipase A activation in the course of perfusion was detectable through the addition of procaine.