Halothane and desflurane requirements in alcohol-tolerant and -nontolerant rats.
Halothane and desflurane requirements in alcohol-tolerant and -nontolerant rats.
复制标题
耐酒精和不耐酒精大鼠的氟烷和地氟烷需求。
DOI：
10.1093/bja/85.5.757
复制
发表时间：
2000
影响因子：
9.8
通讯作者：
Quinlan,JJ
中科院分区：
文献类型：
--
作者：
Firestone,LL;Korpi,ER;Niemi,L;Rosenberg,PH;Homanics,GE;Quinlan,JJ
On the basis of data implicating GABAAreceptors in the effects of volatile general anaesthetics, we hypothesized that alcohol‐, barbiturate‐, and benzodiazepine‐sensitive alcohol‐nontolerant (ANT) rats would also be more sensitive than alcohol‐tolerant (AT) rats to two clinical general anaesthetics with differing potencies, halothane and desflurane. The obtunding effect of halothane and desflurane on mature ANT (n=17) and AT (n=16) rats was assessed by the loss‐of‐righting reflex endpoint. ANT rats were significantly (P<0.0001) more sensitive to the obtunding effects of both halothane and desflurane (ED50=0.45±0.03% atm for ANTvs0.95±0.04% atm for AT and 2.16±0.17vs3.69±0.13% atm, respectively). The immobilization effect of halothane and desflurane was assessed with the tail clamp/withdrawal endpoint. ANT rats were more sensitive to the effects of halothane (ED50=1.10±0.08% atm for ANTvs1.72±0.09% atm for AT;P<0.0001) but not desflurane (ED50=6.25±0.25% atm for ANTvs5.85±0.21% atm for AT). The data presented support the hypothesis that volatile anaesthetics interact with specific neuronal proteins (possibly GABAAreceptors) and agree with recent hypotheses that different elements of the anaesthetic state are produced by separate sites or mechanisms.Br J Anaesth85; 2000: 757–62
