Wnt signaling in the regulation of adult hippocampal neurogenesis.
Wnt signaling in the regulation of adult hippocampal neurogenesis.
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DOI：
10.3389/fncel.2013.00100
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发表时间：
2013
影响因子：
5.3
通讯作者：
Inestrosa NC
中科院分区：
文献类型：
--
作者：
Varela-Nallar L;Inestrosa NC
在成年脑中，新生神经元主要在两个区域持续产生，即侧脑室的脑室下区（SVZ）和海马齿状回的颗粒下区（SGZ）。在SGZ中，放射状神经干细胞（NSC）产生颗粒细胞，其整合到海马回路中，并且与海马的可塑性相关。神经发生的丧失损害学习和记忆，表明这一过程对成年海马功能很重要。成体神经发生受到多种信号通路的严格调节，包括经典的Wnt/β-catenin通路。该通路在神经元回路的发育过程中起着重要作用，并且在成人大脑中，它调节突触传递和可塑性。本文就Wnt/β-catenin信号级联反应调控成年海马神经发生的研究进展及其可能的调控机制作一综述。我们还讨论了支持经典Wnt通路是参与不同生理条件下神经发生调节的信号机制的一部分的证据。最后，一些未解决的问题，关于Wnt介导的调节神经发生进行了讨论。
In the adult brain new neurons are continuously generated mainly in two regions, the subventricular zone (SVZ) of the lateral ventricles and the subgranular zone (SGZ) in the hippocampal dentate gyrus. In the SGZ, radial neural stem cells (NSCs) give rise to granule cells that integrate into the hippocampal circuitry and are relevant for the plasticity of the hippocampus. Loss of neurogenesis impairs learning and memory, suggesting that this process is important for adult hippocampal function. Adult neurogenesis is tightly regulated by multiple signaling pathways, including the canonical Wnt/β-catenin pathway. This pathway plays important roles during the development of neuronal circuits and in the adult brain it modulates synaptic transmission and plasticity. Here, we review current knowledge on the regulation of adult hippocampal neurogenesis by the Wnt/β-catenin signaling cascade and the potential mechanisms involved in this regulation. Also we discuss the evidence supporting that the canonical Wnt pathway is part of the signaling mechanisms involved in the regulation of neurogenesis in different physiological conditions. Finally, some unsolved questions regarding the Wnt-mediated regulation of neurogenesis are discussed.
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