The prevalence of benign and malignant tumors in patients with acromegaly at a single institute
The prevalence of benign and malignant tumors in patients with acromegaly at a single institute
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DOI：
10.1507/endocrj.k07e-010
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发表时间：
2008-02-01
影响因子：
2
通讯作者：
Takano, Kazue
中科院分区：
文献类型：
--
作者：
Kurimoto, Makiko;Fukuda, Izumi;Takano, Kazue
据报道，肢端肥大症患者可能会增加患几种癌症的风险，如结直肠癌、乳腺癌和前列腺癌。然而，一些报告并不支持这些发现，因此肢端肥大症患者的癌症患病率仍然存在争议。在这项研究中，我们确定了肢端肥大症患者的良性和恶性肿瘤的患病率。对140例曾在我们门诊就诊的活动性肢端肥大症患者（男性/女性54/86，年龄55 ± 125岁，范围21-86）进行了回顾性图表分析。结肠癌10例，甲状腺癌5例，乳腺癌4例，胃癌2例。与当地人群相比，女性肢端肥大症患者甲状腺癌的标准化发病率比（SIR）为61.74（95%置信区间（CI）：0.51-114.63），男性为272.4（95% CI：29.12-876.71）。与当地人群相比，肢端肥大症患者中结肠癌的SIR为女性17.4（95%CI：4.74-44.55），男性19.0（95%CI：5.18-48.64）。良性肿瘤中，结节性甲状腺肿占57%（47/83），结肠息肉占39%（31/80），胃息肉占21%（8/39），胆囊息肉占15%（10/65）。这项研究表明，肢端肥大症患者患结肠癌和息肉的风险增加。此外，据推测，男性患者患甲状腺癌的风险增加。因此，建议肢端肥大症患者应进行筛查结肠镜检查和甲状腺超声检查。
It has been reported that patients with acromegaly may have an increased risk of developing several types of cancers, such as colorectal, breast and prostate tumors. However, some reports do not Support these findings and therefore the prevalence of cancers in patients with acromegaly remains controversial. In this study, we determined the prevalence of benign and malignant neoplasms in patients with acromegaly. A retrospective chart analysis was performed on 140 patients with active acromegaly who had attended our outpatient clinic (M/F 54/86, age 55 +/- 125 yr, range 21-86). Colon cancer was found in 10 patients, thyroid cancer in 5, breast cancer in 4 and gastric cancer in 2. When compared with the local population, the standardized incidence ratios (SIRs) for thyroid cancer in patients with acromegaly were 61.74 (95% confidence interval (Cl): 0.51-114.63) for females and 272.4 (95% CI: 29.12-876.71) for males. The SIRs for colon cancer in the acromegalic patients were 17.4 (95% CI: 4.74-44.55) for females and 19.0 (95% CI: 5.18-48.64) for male patients in comparison with the local population. Of the benign tumors, multinodular goiter and colonic, gastric and gallbladder polyps were observed in 57% (47/83), 39% (31/80), 21% (8/39), and 15% (10/65) of the patients, respectively. This study suggested that patients with acromegaly have an increased risk of colon cancer and polyps. Moreover, it is speculated that the risk for thyroid cancer is increased in male patients. It is therefore recommended that patients with acromegaly should undergo screening colonoscopy and ultrasonography of the thyroid.