Polymorphisms of the XPC gene may contribute to the risk of head and neck cancer: a meta-analysis
Polymorphisms of the XPC gene may contribute to the risk of head and neck cancer: a meta-analysis
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XPC 基因的多态性可能会增加头颈癌的风险：一项荟萃分析
DOI：
10.1007/s13277-013-1520-6
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发表时间：
2014-04
期刊：
影响因子：
--
通讯作者：
黄志刚
中科院分区：
文献类型：
--
作者：
黄志刚
据报道，XPC基因的多态性与头颈癌（HNC）的风险增加有关，尽管确切的生物学效应仍不清楚。遗传关联研究（GAS）调查了XPC基因的三种常见多态性（PAT，Lys 939 Gln和Ala 499 Val）与HNC风险之间的关联，产生了矛盾和不确定的结果。这项荟萃分析的目的是评估这些多态性对HNC风险的贡献。在PubMed、Embase、Web of Science、科克伦图书馆和中国国家知识基础设施数据库中进行文献检索，以识别合格的研究。根据异质性检验，在固定效应或随机效应模型下，使用合并比值比（OR）和95%置信区间（95% CI）评估相关性的强度。本荟萃分析纳入了12项病例对照研究，共纳入3，078例HNC患者和4，311例健康对照。对于XPC PAT，在所有主要遗传模型下均发现了显著的总体关联。分层分析进一步表明，在高加索人、基于人群、非PCR-RFLP、食管癌和口腔癌亚组中存在显著相关性。对于XPC Lys 939 Gln，在总体分析或分层分析中均未发现显著结果。对于XPC Ala 499 Val，合并结果显示499 Val等位基因携带者的HNC风险显著增加。这项荟萃分析显示，XPC PAT和Ala 499 Val多态性可能与HNC风险增加相关，而XPC Lys 939 Gln可能与HNC风险无关。尽管存在一些局限性，但该荟萃分析为XPC基因多态性与HNC风险之间的关联建立了坚实的统计学证据，值得进一步验证。
Polymorphisms of the XPC gene have been reported to be associated with an increased risk of head and neck cancer (HNC), though the exact biological effect is still unclear. Genetic association studies (GAS) investigating the associations between three common polymorphisms (PAT, Lys939Gln, and Ala499Val) of the XPC gene and HNC risk have produced contradictory and inconclusive results. The aim of this meta-analysis is to evaluate the contributions of these polymorphisms to the risk of HNC. A literature search was conducted in the PubMed, Embase, Web of Science, Cochrane Library, and China National Knowledge Infrastructure databases to indentify eligible studies. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were used to evaluate the strength of the associations under a fixed- or random-effect model according to heterogeneity test. Twelve case-control studies were included in this meta-analysis with a total of 3,078 HNC patients and 4,311 healthy controls. For XPC PAT, a significant overall association was found under all major genetic models. Stratified analyses further indicated significant associations in the Caucasian, population-based, non-PCR-RFLP, esophageal cancer and oral cancer subgroups. For XPC Lys939Gln, few significant results were found in either the overall analysis or stratified analyses. For XPC Ala499Val, the combined results revealed a significantly increased risk of HNC for carriers of the 499Val allele. This meta-analysis shows that the XPC PAT and Ala499Val polymorphisms may be associated with an increased risk of HNC, while XPC Lys939Gln may not be associated with HNC risk. Despite some limitations, this meta-analysis establishes solid statistical evidence for an association between XPC genetic polymorphisms and HNC risk that warrants further validation.
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DOI：
10.1007/978-0-387-48894-3_10
发表时间：
2013
期刊：
--
影响因子：
--
作者：
H. Schöder
通讯作者：
H. Schöder
DOI：
10.1891/9780826121646.0002
发表时间：
2018-09
期刊：
Cancer Rehabilitation
影响因子：
--
作者：
K. Miller;R. Siegel;R. Khan;A. Jemal
通讯作者：
K. Miller;R. Siegel;R. Khan;A. Jemal
DOI：
10.1136/bmj.b2535
发表时间：
2009-07-21
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者：
PRISMA Group
影响因子：
2
作者：
Jackson, Dan;White, Ian R.;Riley, Richard D.
通讯作者：
Riley, Richard D.
影响因子：
4.7
作者：
A. Casson;Zuoyu Zheng;S. Evans;P. Veugelers;G. Porter;D. Guernsey
通讯作者：
A. Casson;Zuoyu Zheng;S. Evans;P. Veugelers;G. Porter;D. Guernsey