Positive and negative modulation of motor response in primate superior colliculus by reward expectation
Positive and negative modulation of motor response in primate superior colliculus by reward expectation
复制标题
DOI：
10.1152/jn.00975.2007
复制
发表时间：
2007-12-01
影响因子：
2.5
通讯作者：
Hikosaka, Okihide
中科院分区：
文献类型：
--
作者：
Ikeda, Takuro;Hikosaka, Okihide
奖赏期望对灵长类动物上级丘运动反应的正性和负性调节。神经生理学杂志98：3163-3170，2007年。首次发表于2007年10月10日; doi：10.1152/jn.00975.2007。对奖励的期望是动物目标导向行为的关键。然而，人们对奖励信息在行动时如何在大脑中使用知之甚少。我们调查了这个问题，从猕猴上级丘（SC）的单个神经元记录，而动物正在执行一个记忆引导的眼跳任务与不对称的奖励时间表。SC是提出这个问题的理想结构，因为它接收来自许多大脑区域的输入，包括前额叶皮层和基底神经节，其中奖励信息被认为是编码的，并将运动命令发送到脑干扫视发生器。我们发现两组SC神经元编码的奖励信息在preaccadic期间：积极的奖励编码神经元，表现出较高的活动时，奖励预期和负奖励编码神经元，表现出较高的活动时，奖励没有预期。积极的奖励编码通常甚至在提示目标位置之前就开始了，而消极的奖励编码则主要局限于前阶段。这两种奖赏编码可能有助于动物在复杂环境中选择适当的行为。
Positive and negative modulation of motor response in primate superior colliculus by reward expectation. J Neurophysiol 98: 3163-3170, 2007. First published October 10, 2007; doi:10.1152/jn.00975.2007. Expectation of reward is crucial for goal-directed behavior of animals. However, little is known about how reward information is used in the brain at the time of action. We investigated this question by recording from single neurons in the macaque superior colliculus (SC) while the animal was performing a memory-guided saccade task with an asymmetrical reward schedule. The SC is an ideal structure to ask this question because it receives inputs from many brain areas including the prefrontal cortex and the basal ganglia where reward information is thought to be encoded and sends motor commands to the brain stem saccade generators. We found two groups of SC neurons that encoded reward information in the presaccadic period: positive reward-coding neurons that showed higher activity when reward was expected and negative reward-coding neurons that showed higher activity when reward was not expected. The positive reward-coding usually started even before a cue for target position was presented, whereas the negative reward-coding was largely restricted to the presaccadic period. The two kinds of reward-coding may be useful for the animal to select an appropriate behavior in a complex environment.