SUMMATION AND DIVISION BY NEURONS IN PRIMATE VISUAL-CORTEX
SUMMATION AND DIVISION BY NEURONS IN PRIMATE VISUAL-CORTEX
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DOI：
10.1126/science.8191289
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发表时间：
1994-05-27
期刊：
影响因子：
56.9
通讯作者：
HEEGER, DJ
中科院分区：
文献类型：
--
作者：
CARANDINI, M;HEEGER, DJ
猴子初级视皮层(V1)的记录被用来测试一个简单细胞视觉驱动反应的模型。根据该模型，简单细胞计算外侧膝状体(LGN)神经元的反应的线性和。此外，每个简单细胞的线性反应除以大量其他简单细胞的共同活动。细胞膜执行这两种操作；将突触电流相加，然后除以总的膜电导。电流和电导是分离的(通过激励和抑制的互补安排)，因此电流仅取决于LGN输入，而电导仅取决于大脑皮层输入。推导出闭合形式的表达式，用于对生理数据进行拟合和解释。该模型准确地预测了对不同对比度、方向和时空频率的漂移光栅刺激的响应。
Recordings from monkey primary visual cortex (V1) were used to test a model for the visually driven responses of simple cells. According to the model, simple cells compute a linear sum of the responses of lateral geniculate nucleus (LGN) neurons. In addition, each simple cell's linear response is divided by the pooled activity of a large number of other simple cells. The cell membrane performs both operations; synaptic currents are summed and then divided by the total membrane conductance. Current and conductance are decoupled (by a complementary arrangement of excitation and inhibition) so that current depends only on the LGN inputs and conductance depends only on the cortical inputs. Closed form expressions were derived for fitting and interpreting physiological data. The model accurately predicted responses to drifting grating stimuli of various contrasts, orientations, and spatiotemporal frequencies.