Harmaline, a potent inhibitor of sodium-dependent transport.
Harmaline, a potent inhibitor of sodium-dependent transport.
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Harmaline，钠依赖性转运的有效抑制剂。
DOI：
10.1016/0005-2736(74)90035-2
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发表时间：
1974
期刊：
影响因子：
--
通讯作者：
J. Robinson
中科院分区：
文献类型：
--
作者：
F. Sepúlveda;J. Robinson
骆驼蓬碱是一种致幻生物碱，在短期和长期孵育过程中，它在体外抑制豚鼠肠道粘膜的糖和氨基酸运输。它影响其他组织中的钠依赖转运系统，如狗的结肠粘膜和肾皮质切片，但不影响钠非依赖性转运。无论有无非电解质，它都能抑制钠进入肠环。有人认为骆驼蓬碱与转运载体在肠和肾细胞膜上的钠结合部位相互作用。
Harmaline, a hallucinogenic alkaloid, inhibits sugar and amino acid transport by the guinea-pig intestinal mucosa in vitro during short and long incubations. It affects sodium-dependent transport systems in other tissues such as the dog colonic mucosa and renal cortex slices, but does not influence sodium-independent transport. It inhibits sodium entry into intestinal rings, both in the presence and absence of non-electrolytes. It is proposed that harmaline interacts with the sodium-binding site of the transport carriers in the membranes of intestinal and renal cells.