THE HUMAN HOMOLOGS OF THE RAF (MIL) ONCOGENE ARE LOCATED ON HUMAN CHROMOSOME-3 AND CHROMOSONE-4
THE HUMAN HOMOLOGS OF THE RAF (MIL) ONCOGENE ARE LOCATED ON HUMAN CHROMOSOME-3 AND CHROMOSONE-4
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DOI：
10.1126/science.6691137
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发表时间：
1984-01-01
期刊：
影响因子：
56.9
通讯作者：
LEDER, P
中科院分区：
文献类型：
--
作者：
BONNER, T;OBRIEN, SJ;LEDER, P
与鼠转化基因（癌基因）v. -v. raf和鸡转化基因nu. -通过人-啮齿动物体细胞杂交将MIL定位到先前缺乏已知致癌基因的人染色体上。其中一个基因c-raf-2位于4号染色体上，似乎是一个经过加工的假基因。另一个基因，c-raf-1，这似乎是活跃的基因，位于3号染色体上，并通过染色体原位杂交定位到3 p25。这种分配与某些人类恶性肿瘤相关的特定染色体异常相关。
Two human genes that are homologous to both the murine transforming gene (oncogene) .nu.-raf and the chicken transforming gene .nu.-mil were mapped by means of human-rodent somatic cell hybrids to human chromosomes previously devoid of known oncogenes. One gene, c-raf-2, which appears to be a processed pseudogene, is located on chromosome 4. The other gene, c-raf-1, which appears to be the active gene, is located on chromosome 3 and was regionally mapped by chromosomal in situ hybridization to 3p25. This assignment correlates with specific chromosomal abnormalities associated with certain human malignancies.