ON THE HYDRODYNAMIC ANALYSIS OF MACROMOLECULAR CONFORMATION
ON THE HYDRODYNAMIC ANALYSIS OF MACROMOLECULAR CONFORMATION
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DOI：
10.1016/0301-4622(94)00143-8
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发表时间：
1995-06-01
影响因子：
3.8
通讯作者：
HARDING, SE
中科院分区：
文献类型：
--
作者：
HARDING, SE
流体力学为传统的高分辨率技术提供了强有力的补充作用，用于研究大分子构象，特别是在稀溶液中，这些条件通常是其他结构技术无法达到的。本文从（1）简单而直接的旋转椭球模型;（2）一般的三轴椭球模型;（3）流体动力学珠模型;（4）区分各种构象类型的能力，特别是对于多分散大分子系统;（5）大分子柔性分析等方面介绍了大分子构象的流体动力学表示的现状。
Hydrodynamics provides a powerful complementary role to the traditional ''high resolution'' techniques for the investigation of macromolecular conformation, especially in dilute solution, conditions which are generally inaccessible to other structural techniques. This paper describes the state of art of hydrodynamic representations for macromolecular conformation, in terms of (1) simple but straightforward ellipsoid of revolution modelling; (2) general triaxial ellipsoid modelling; (3) hydrodynamic bead modelling; (4) the ability, especially for polydisperse macromolecular systems, to distinguish between various conformation types; (5) analysis of macromolecular flexibility.