Effects of Omega-3 in the treatment of violent schizophrenia patients
Effects of Omega-3 in the treatment of violent schizophrenia patients
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DOI：
10.1016/j.schres.2017.08.026
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发表时间：
2018-05-01
影响因子：
4.5
通讯作者：
Long, Bin
中科院分区：
文献类型：
--
作者：
Qiao, Yi;Mei, Yi;Long, Bin
目的：本研究旨在探讨每日食用鱼油（360 mg DHA + 540 mg EPA）与精神分裂症患者症状和暴力行为减轻的关系。方法：50名符合ICD-10精神分裂症标准且接受抗精神病药物治疗的改良显性攻击量表（MOAS）评分超过4分的住院患者被随机分配接受鱼油（N = 28）或安慰剂（N = 22），进行为期12周的双盲补充试验。在基线和第4、8和12周进行评估。结果：治疗后4、8、12周PANSS、CGI评分均下降，但两组间无显著性差异。MOAS评分在第4、8和12周显著下降。第12周，鱼油组MOAS评分较安慰剂组明显下降（t =-2.40，P < 0.05）。结论：用鱼油（360毫克DHA + 540毫克EPA）治疗的暴力精神分裂症患者表现出暴力行为的减少，但在12周后，阳性和阴性症状的改善并不比用安慰剂治疗的患者大。(C)2017由Elsevier B. V.出版
Objective: This study was designed to explore the relationship in between the daily consumption of fish oil (360 mg DHA + 540 mg EPA), and reduction of symptoms and violent behavior among patients with schizophrenia. Method: Fifty inpatients meeting ICD-10 criteria for schizophrenia and scoring more than four of Modified Overt Aggression Scale (MOAS) with antipsychotics treatment were randomly assigned to receive either fish oil (N = 28) or a placebo (N = 22) in a twelve week, double-blind supplementation trial. Assessments were performed at baseline and at weeks 4, 8 and 12. Results: The PANSS and CGI scores decreased at the week of 4, 8 and 12, but no differences were found between the two groups. MOAS scores declined significantly at weeks 4, 8 and 12. At week 12, MOAS scores of the fish oil group declined significantly than the placebo group (t = -2.40, P < 0.05). Conclusions: violent schizophrenia patients treated with fish oil (360 mg DHA + 540 mg EPA) demonstrated a decrease in violence, but improvement in positive and negative symptoms was no greater than patients treated with the placebo after twelve weeks. (C) 2017 Published by Elsevier B.V.