Electrical Stimulation to Promote Peripheral Nerve Regeneration
Electrical Stimulation to Promote Peripheral Nerve Regeneration
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DOI：
10.1177/1545968315604399
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发表时间：
2016-06-01
影响因子：
4.2
通讯作者：
Gordon, Tessa
中科院分区：
文献类型：
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作者：
Willand, Michael P.;May-Anh Nguyen;Gordon, Tessa
周围神经损伤困扰着各行各业的人。尽管周围神经系统具有内在的再生能力，但许多患者的功能恢复不完全。手术修复旨在以最彻底的方式加快这一恢复过程。然而，完全恢复仍然很少见到，特别是当神经损伤与多发性创伤复合时，手术修复延迟。已经研究了神经显微手术的药物补充策略，但手术仍然是唯一可行的选择。短期低频电刺激的近端神经残端后，初步修复已被广泛研究。本文旨在回顾目前已知的生物学基础的再生效果的急性短暂的低频电刺激轴突再生和概述最近的临床应用的电刺激协议，以证明显着的翻译潜力，这种方式修复周围神经损伤。审查的结论是在这一令人兴奋的研究领域的新进展的讨论。目前的文献表明，手术修复后急性短暂低频电刺激的临床适用性迫在眉睫，以有效地促进轴突再生，因为刺激已经产生了有希望的证据，以最大限度地恢复各种类型的周围神经损伤的功能。
Peripheral nerve injury afflicts individuals from all walks of life. Despite the peripheral nervous system's intrinsic ability to regenerate, many patients experience incomplete functional recovery. Surgical repair aims to expedite this recovery process in the most thorough manner possible. However, full recovery is still rarely seen especially when nerve injury is compounded with polytrauma where surgical repair is delayed. Pharmaceutical strategies supplementary to nerve microsurgery have been investigated but surgery remains the only viable option. Brief low-frequency electrical stimulation of the proximal nerve stump after primary repair has been widely investigated. This article aims to review the currently known biological basis for the regenerative effects of acute brief low-frequency electrical stimulation on axonal regeneration and outline the recent clinical applications of the electrical stimulation protocol to demonstrate the significant translational potential of this modality for repairing peripheral nerve injuries. The review concludes with a discussion of emerging new advancements in this exciting area of research. The current literature indicates the imminent clinical applicability of acute brief low-frequency electrical stimulation after surgical repair to effectively promote axonal regeneration as the stimulation has yielded promising evidence to maximize functional recovery in diverse types of peripheral nerve injuries.