Lipid metabolism reprogramming and its potential targets in cancer.
Lipid metabolism reprogramming and its potential targets in cancer.
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DOI：
10.1186/s40880-018-0301-4
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发表时间：
2018-05-21
期刊：
影响因子：
--
通讯作者：
Guo D
中科院分区：
文献类型：
--
作者：
Cheng C;Geng F;Cheng X;Guo D
脂质代谢的重编程是一个新认识的恶性肿瘤的标志。增加的脂质摄取、储存和脂肪生成发生在各种癌症中，并有助于肿瘤的快速生长。脂质构成了膜的基本结构，也起到信号分子和能量来源的作用。固醇调节元件结合蛋白（SREBPs）是内质网中的一个膜结合转录因子家族，在脂质代谢的调节中起着重要作用。最近的研究表明，SREBP在各种癌症中高度上调，并促进肿瘤生长。SREBP裂解激活蛋白（SREBP cleavage-activating protein，SREBP）是SREBP运输和激活的关键转运蛋白，也是连接糖代谢和脂质从头合成的关键葡萄糖传感器。靶向改变的脂质代谢途径已成为一种有前途的抗癌策略。本文综述了近年来对恶性肿瘤脂质代谢调控的研究进展，并重点介绍了肿瘤治疗的潜在分子靶点及其抑制剂。
Reprogramming of lipid metabolism is a newly recognized hallmark of malignancy. Increased lipid uptake, storage and lipogenesis occur in a variety of cancers and contribute to rapid tumor growth. Lipids constitute the basic structure of membranes and also function as signaling molecules and energy sources. Sterol regulatory element-binding proteins (SREBPs), a family of membrane-bound transcription factors in the endoplasmic reticulum, play a central role in the regulation of lipid metabolism. Recent studies have revealed that SREBPs are highly up-regulated in various cancers and promote tumor growth. SREBP cleavage-activating protein is a key transporter in the trafficking and activation of SREBPs as well as a critical glucose sensor, thus linking glucose metabolism and de novo lipid synthesis. Targeting altered lipid metabolic pathways has become a promising anti-cancer strategy. This review summarizes recent progress in our understanding of lipid metabolism regulation in malignancy, and highlights potential molecular targets and their inhibitors for cancer treatment.
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DOI：
10.1007/s12032-014-0391-z
发表时间：
2015-01
期刊：
Medical oncology (Northwood, London, England)
影响因子：
--
作者：
Cai Y;Wang J;Zhang L;Wu D;Yu D;Tian X;Liu J;Jiang X;Shen Y;Zhang L;Ren M;Huang P
通讯作者：
Huang P
影响因子：
6.5
作者：
Amemiya-Kudo, M;Shimano, H;Yamada, N
通讯作者：
Yamada, N
影响因子：
64.8
作者：
Bai Y;McCoy JG;Levin EJ;Sobrado P;Rajashankar KR;Fox BG;Zhou M
通讯作者：
Zhou M
影响因子：
6.4
作者：
Carvalho, Marco A.;Zecchin, Karina G.;Graner, Edgard
通讯作者：
Graner, Edgard
影响因子：
8
作者：
Bauer, DE;Hatzivassiliou, G;Thompson, CB
通讯作者：
Thompson, CB