Cochlin-cleaved LCCL is a dual-armed regulator of the innate immune response in the cochlea during inflammation.
Cochlin-cleaved LCCL is a dual-armed regulator of the innate immune response in the cochlea during inflammation.
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DOI：
10.5483/bmbrep.2020.53.9.104
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发表时间：
2020-09
期刊：
影响因子：
3.8
通讯作者：
Hyun YM
中科院分区：
文献类型：
--
作者：
Rhyu HJ;Bae SH;Jung J;Hyun YM
内耳是由耳蜗和前庭系统组成的复杂而精细的结构。为了维持正常的听觉功能，内耳需要严格的动态平衡。因此，针对感染的适当免疫反应至关重要。此外，由于过度的免疫反应很容易破坏内耳内的正常结构，因此免疫反应应该得到很好的调节。内耳的免疫反应，特别是先天免疫是如何被调节的确切机制尚不清楚。最近，我们报道了一种在细菌感染过程中选择性地定位于内耳的蛋白质，名为cochlin，可能是这种调节的媒介。本文就Cochlin的免疫功能及其在内耳免疫中的作用机制作一综述。Cochlin通过物理捕获鼓阶内的病原体并招募先天免疫细胞来调节先天免疫。这种机制可以有效地清除病原体，同时保护正常的内耳结构不受炎症损害。
The inner ear is a complex and delicate structure composed of the cochlea and the vestibular system. To maintain normal auditory function, strict homeostasis of the inner ear is needed. A proper immune response against infection, thus, is crucial. Also, since excessive immune reaction can easily damage the normal architecture within the inner ear, the immune response should be fine regulated. The exact mechanism how the inner ear’s immune response, specifically the innate immunity, is regulated was unknown. Recently, we reported a protein selectively localized in the inner ear during bacterial infection, named cochlin, as a possible mediator of such regulation. In this review, the immunological function of cochlin and the mechanism behind its role within inner ear immunity is sum-marized. Cochlin regulates innate immunity by physically en-trapping pathogens within scala tympani and recruiting innate immune cells. Such mechanism enables efficient removal of pathogen while preserving the normal inner ear structure from inflammatory damage.