Behavioral weight loss for the management of menopausal hot flashes: a pilot study.
Behavioral weight loss for the management of menopausal hot flashes: a pilot study.
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DOI：
10.1097/gme.0000000000000274
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发表时间：
2015-01
期刊：
影响因子：
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通讯作者：
Levine MD
中科院分区：
文献类型：
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作者：
Thurston RC;Ewing LJ;Low CA;Christie AJ;Levine MD
虽然肥胖被认为可以预防潮热，但最新的数据表明潮热和肥胖之间存在正相关关系。没有专门设计的研究来测试减肥是否会减少潮热。这项初步研究旨在评估行为减肥减少潮热的可行性、可接受性和初步疗效。40名超重/肥胖伴潮热（≥4次/天）的女性被随机分配至行为减肥干预组或等待名单对照组。通过生理监测仪、日记和问卷调查评估干预前后的潮热。通过Wilcoxon检验比较不同条件下潮热和人体测量学的变化。研究保留率（83%）和干预满意度（93.8%）都很高。大多数女性（74.1%）报告说，减少潮热是减肥的主要动力。随机分配到减肥干预组的妇女比随机分配到对照组的妇女减掉了更多的体重（-8.86公斤）（+0.23公斤，p<.0001）。随机分配到减肥组的女性也显示出比对照组的女性（-28.0，p=.03）更大的患者报告的潮热减少（2周潮热：-63.0），在其他潮热测量中没有表现出差异。体重减轻和潮热显著相关（例如，r= 0.47，p= 0.006）。这项初步研究表明，行为减肥计划是可行的，可接受的，并有效地产生体重减轻超重/肥胖妇女潮热。研究结果表明，一个更大的研究，旨在测试行为减肥减少潮热的重要性。潮热管理可以激励女性参与这种促进健康的行为。
Although adiposity has been considered protective against hot flashes, newer data suggest positive relations between flashes and adiposity. No studies have been specifically designed to test whether weight loss reduces hot flashes. This pilot study aimed to evaluate the feasibility, acceptability, and initial efficacy of behavioral weight loss to reduce hot flashes. Forty overweight/obese women with hot flashes (≥4/day) were randomized to a behavioral weight loss intervention or to wait list control. Hot flashes were assessed pre- and post-intervention via physiologic monitor, diary, and questionnaire. Comparisons of changes in hot flashes and anthropometrics between conditions were tested via Wilcoxon tests. Study retention (83%) and intervention satisfaction (93.8%) were high. Most women (74.1%) reported that hot flash reduction was a main motivator to lose weight. Women randomized to the weight loss intervention lost more weight (-8.86 kg) than did women randomized to control (+0.23 kg, p<.0001). Women randomized to weight loss also showed greater reductions in questionnaire-reported hot flashes (2-week hot flashes: −63.0) than did women in the control (−28.0, p=.03), a difference not demonstrated in other hot flash measures. Reductions in weight and hot flashes were significantly correlated (e.g., r=.47, p=.006). This pilot study showed a behavioral weight loss program to be feasible, acceptable, and effective in producing weight loss among overweight/obese women with hot flashes. Findings indicate the importance of a larger study designed to test behavioral weight loss for hot flash reduction. Hot flash management could motivate women to engage in this health-promoting behavior.