Epidemiology of nasopharyngeal carcinoma in the United States: improved survival of Chinese patients within the keratinizing squamous cell carcinoma histology
Epidemiology of nasopharyngeal carcinoma in the United States: improved survival of Chinese patients within the keratinizing squamous cell carcinoma histology
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DOI：
10.1093/annonc/mdl320
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发表时间：
2007-01-01
影响因子：
50.5
通讯作者：
Anton-Culver, H.
中科院分区：
文献类型：
--
作者：
Ou, S. -H. I.;Zell, J. A.;Anton-Culver, H.
背景：这项研究考察了美国不同种族鼻咽癌患者的潜在生存差异。患者和方法：从基于人群的监测、流行病学和最终结果(SEER)项目中分析了1992-2002年间2436例新诊断的鼻咽癌患者。计算5年生存率估计值和Kaplan-Meier生存曲线。结果：多因素分析显示，早期诊断、就诊时所处的局部阶段(与远期相比，HR=0.35；P<；0.0001)、放射治疗(与无；HR=0.48；P<；0.0001)、未分化非角化性癌(与角化性鳞状细胞癌相比，HR=0.67；P<；0.0001)、华裔(与高加索人相比，HR=0.78；P=0.0010)与生存率的提高有关。在角化性鳞癌组织学中，即使在调整了其他预后因素后，中国患者的生存优势仍然存在。结论：中国人在角化性鳞癌组织学中的显著生存优势在很大程度上是因为华人是影响鼻咽癌患者生存的独立和有利的预后因素。
Background: This study examined potential survival differences among nasopharyngeal carcinoma (NPC) patients from various ethnicities in the United States.Patients and methods: A total of 2436 newly diagnosed NPC patients from 1992 to 2002 were analyzed from the population-based Surveillance, Epidemiology, and End Results (SEER) program. Five-year survival rate estimates and Kaplan-Meier survival curves were calculated. Cox proportional hazard ratios (HRs) were used to identify independent prognostic factors for survival.Results: By multivariate analyses, early age of diagnosis, localized stage at presentation (versus distant, HR=0.35; P < 0.0001), radiation therapy (versus none; HR=0.48; P < 0.0001), undifferentiated non-keratinizing carcinoma (versus keratinizing squamous cell carcinoma; HR=0.67; P < 0.0001), and Chinese ethnicity (versus Caucasian; HR=0.78; P=0.0010) were associated with improved survival. Within keratinizing squamous cell carcinoma histology, the survival advantage of Chinese patients remained even after adjustment for other prognostic factors.Conclusions: The significant survival advantage of Chinese NPC patients within the keratinizing squamous cell carcinoma histology contributed largely to Chinese ethnicity being an independent and favorable prognostic factor for survival in NPC.