Impairment in quality of life is directly related to the level of allergen exposure and allergic airway inflammation
Impairment in quality of life is directly related to the level of allergen exposure and allergic airway inflammation
复制标题
DOI：
10.1111/j.1365-2222.2005.02333.x
复制
发表时间：
2005-10-01
影响因子：
6.1
通讯作者：
Lack, G
中科院分区：
文献类型：
--
作者：
Roberts, G;Mylonopoulou, M;Lack, G
背景变应性疾病已被证明损害健康相关的生活质量（HRQL）。HRQL与过敏原暴露或过敏性炎症之间的关系尚未被以前assessed.Objective评估HRQL与草花粉暴露和气道炎症之间的关系，使用儿科过敏性疾病生活质量问卷（PADQLQ）。这是一个新的问卷调查以前开发的多系统方面的过敏性diseases.Methods 84名受试者，年龄在6-17岁，季节性过敏性鼻结膜炎，哮喘和/或皮肤的表现进行了评估之前和期间的草花粉季节。结果PADQLQ测定的HRQL与前一周平均花粉数呈显著相关（回归系数0.038，95%可信区间（CI）0.027-0.049，P < 0.001）。PADQLQ评分与FENO测定的气道炎症显著相关（回归系数0.410，95%CI 0.175-0.646，P=0.001）。此外，PADQLQ显示与症状评分和生活质量（通过VAS测量）高度相关，受试者内可靠性良好，最小重要差异较小（0.20，结论HRQL与过敏原负荷和过敏性炎症均相关，PADQLQ具有良好的交叉反应性。关于生活质量和症状的截面和纵向效度。
Background Allergic disease has been shown to impair health-related quality of life (HRQL). The relationship between HRQL and either allergen exposure or allergic inflammation has not been previously assessed.Objective To assess the relationship between HRQL and both grass pollen exposure and airway inflammation using the Paediatric Allergic Disease Quality of Life Questionnaire (PADQLQ). This is a novel questionnaire previously developed to assess the multi-system aspects of allergic disease.Methods Eighty-four subjects, aged 6-17 years, with seasonal allergic rhinoconjunctivitis, asthma and/or cutaneous manifestations were assessed before and during the grass pollen season. They were assessed with the PADQLQ, a visual analogue scale (VAS) to assess quality of life, symptom diary and exhaled nitric oxide (FENO).Results HRQL, as measured by the PADQLQ, significantly correlated with the average pollen count in the previous week (regression coefficient 0.038, 95% confidence interval (CI) 0.027-0.049, P < 0.001). The PADQLQ score was also found to be significantly associated with airway inflammation as measured by FENO (regression coefficient 0.410, 95% CI 0.175-0.646, P=0.001). Additionally, PADQLQ showed a high degree of correlation with symptom scores and quality of life as measured by a VAS, good within-subject reliability and a small minimal important difference (0.20, 95% CI -0.09 to 0.49 on a seven-point scale).Conclusion HRQL is related to both allergen load and allergic inflammation and the PADQLQ has excellent cross-sectional and longitudinal validity with respect to quality of life and symptoms.