Ligand binding was acquired during evolution of nuclear receptors
Ligand binding was acquired during evolution of nuclear receptors
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DOI：
10.1073/pnas.94.13.6803
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发表时间：
1997-06-24
影响因子：
11.1
通讯作者：
Laudet, V
中科院分区：
文献类型：
--
作者：
Escriva, H;Safi, R;Laudet, V
核受体超家族除了配体激活的转录因子外，还包括到目前为止还没有被确定的配体的成员。我们证明了孤儿受体在进化树中是随机分布的，并且给定的配基受体在树中的位置与其配体的化学性质之间没有关系。NRs是后生动物特有的，通过对早期和非后生生物中NR相关序列的筛选，对后生动物进化过程中NR基因复制模式的分析表明，目前的NR多样性源于两波基因复制，值得注意的是，我们的结果表明，祖先的NR是一种孤儿受体，在随后的进化中获得了配体结合能力。
The nuclear receptor (NR) superfamily comprises, in addition to ligand-activated transcription factors, members for which no ligand has been identified to date. We demonstrate that orphan receptors are randomly distributed in the evolutionary tree and that there is no relationship between the position of a given liganded receptor in the tree and the chemical nature of its ligand. NRs are specific to metazoans, as revealed by a screen of NR-related sequences in early- and non-metazoan organisms, The analysis of the NR gene duplication pattern during the evolution of metazoans shows that the present NR diversity arose from two waves of gene duplications, Strikingly, our results suggest that the ancestral NR was an orphan receptor that acquired ligand-binding ability during subsequent evolution.