Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD.

Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD.
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DOI:
10.1038/s41598-017-17546-0
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发表时间:
2017-12-15
期刊:
影响因子:
4.6
通讯作者:
Carhart-Harris RL
Carhart-Harris RL
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Atasoy S;Roseman L;Kaelen M;Kringelbach ML;Deco G;Carhart-Harris RL

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最近的研究已开始阐明麦角酸二乙酰胺 (LSD) 对人脑的影响,但其潜在的动力学尚未完全了解。在这里,我们使用了“连接组谐波分解”,这是一种研究大脑状态动态变化的新方法。我们发现 LSD 以频率选择性的方式改变个体谐波大脑状态的能量和功率。值得注意的是,这导致活跃大脑状态的范围扩大,这表明考虑到跨频率的共同激活的非随机增加,大脑动力学的总体重组。有趣的是,LSD 作用下大脑状态的活跃曲目的频率分布紧密遵循幂律,表明临界边缘的动态重新组织。除了目前的发现之外,这些方法还有助于更好地理解健康和疾病中复杂的大脑动态。
Recent studies have started to elucidate the effects of lysergic acid diethylamide (LSD) on the human brain but the underlying dynamics are not yet fully understood. Here we used ’connectome-harmonic decomposition’, a novel method to investigate the dynamical changes in brain states. We found that LSD alters the energy and the power of individual harmonic brain states in a frequency-selective manner. Remarkably, this leads to an expansion of the repertoire of active brain states, suggestive of a general re-organization of brain dynamics given the non-random increase in co-activation across frequencies. Interestingly, the frequency distribution of the active repertoire of brain states under LSD closely follows power-laws indicating a re-organization of the dynamics at the edge of criticality. Beyond the present findings, these methods open up for a better understanding of the complex brain dynamics in health and disease.
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发表时间: 2010
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