CHEMISTRY AND BIOLOGY OF THE IMMUNOPHILINS AND THEIR IMMUNOSUPPRESSIVE LIGANDS
CHEMISTRY AND BIOLOGY OF THE IMMUNOPHILINS AND THEIR IMMUNOSUPPRESSIVE LIGANDS
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DOI：
10.1126/science.1702904
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发表时间：
1991-01-18
期刊：
影响因子：
56.9
通讯作者：
SCHREIBER, SL
中科院分区：
文献类型：
--
作者：
SCHREIBER, SL
环孢菌素A、FK506和雷帕霉素是导致T淋巴细胞活化的特定信号转导途径的抑制剂。这些免疫抑制剂与细胞质受体结合，称为免疫亲和素(免疫抑制结合蛋白)。这一领域的研究主要集中在免疫亲和素对免疫抑制剂的分子识别的结构基础及其相互作用的生物学后果。明确这个新出现的受体家族及其配体的生物学作用可能会阐明蛋白质在细胞内的运输过程和通过细胞质的信号传递机制。
Cyclosporin A, FK506, and rapamycin are inhibitors of specific signal transduction pathways that lead to T lymphocyte activation. These immunosuppressive agents bind with high affinity to cytoplasmic receptors termed immunophilins (immunosuppressant binding proteins). Studies in this area have focused on the structural basis for the molecular recognition of immunosuppressants by immunophilins and the biological consequences of their interactions. Defining the biological roles of this emerging family of receptors and their ligands may illuminate the process of protein trafficking in cells and the mechanisms of signal transmission through the cytoplasm.