Ni-catalyzed nucleophilic conjugate additions of Grignard and organozincate reagents to substituted 4-vinylpyridines. General synthesis of phosphodiesterase IV inhibitors.
Ni-catalyzed nucleophilic conjugate additions of Grignard and organozincate reagents to substituted 4-vinylpyridines. General synthesis of phosphodiesterase IV inhibitors.
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DOI：
10.1016/s0040-4020(97)10217-4
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发表时间：
1998-02-12
期刊：
影响因子：
2.1
通讯作者：
Reider, PJ
中科院分区：
文献类型：
--
作者：
Houpis, IN;Lee, J;Reider, PJ
烷基、芳基和乙烯基格氏试剂在Ni(Acac)(2)或Cl2Ni(PPh3)(2)催化下与烯烃II加成，得到通式I的产物，产率74-95%。有机锌盐以镍(Acac)为催化剂得到类似的结果，(C)1998爱思唯尔科学有限公司。
Alkyl, aryl, and vinyl Grignard reagents were added to olefin II under Ni(acac)(2) or Cl2Ni(PPh3)(2) catalysis to give products with the general formula I in 74-95% yield. Organozincates gave similar results with Ni(acac), as the catalyst, (C) 1998 Elsevier Science Ltd. All rights reserved.