Ageing and respiratory infections: The airway of ageing
Ageing and respiratory infections: The airway of ageing
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DOI：
10.1016/j.imlet.2014.06.009
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发表时间：
2014-11-01
影响因子：
4.4
通讯作者：
McElhaney, Janet E.
中科院分区：
文献类型：
--
作者：
Haq, Kamran;McElhaney, Janet E.
呼吸道感染是全球传染病负担的主要原因，尤其是在老年人中。此外，据报告，衰老与感染易感性之间存在直接关系，这可能是由于免疫功能受损、身体虚弱和接触传染病的程度。许多复杂的变化，包括结构性和年龄相关的免疫力下降，与全球肺部疾病的增加有关，并导致与年龄相关的疾病负担。对老年人构成严重风险的常见呼吸道感染包括流感、呼吸道合胞病毒和一些细菌病原体，包括肺炎球菌和结核病。这些病原体的疫苗数量有限，包括流感、肺炎球菌和百日咳疫苗。这篇小型综述文章研究了与年龄相关的免疫功能变化，这些变化使老年人易患呼吸道感染和疫苗有效性的潜在丧失，重点关注老龄化和流感感染。(C)2014爱思唯尔有限公司版权所有。
Respiratory infections are a leading cause of infectious disease burden worldwide especially among the elderly. Furthermore, a direct relationship between ageing and susceptibility to infections has been reported, which may be caused by impaired immune function, frailty and degree of exposure to infectious diseases. Many complex changes, including structural and age-associated decline in immunity are associated with increased pulmonary diseases worldwide and result in a high age-related disease burden. The common respiratory infections that present serious risks for the elderly include influenza, respiratory syncytial virus, and a number of bacterial pathogens including pneumococcus and tuberculosis. Vaccines are available for a limited number of these pathogens including influenza, pneumococcal and pertussis vaccines. This mini review article examines the age-related changes in immune function that predispose the elderly population to respiratory infections and potential loss of vaccine efficacy with a focus on ageing and influenza infections. (C) 2014 Elsevier B.V. All rights reserved.