Red Blood Cell Distribution Width as a Predictor of 28-Day Mortality in Critically Ill Patients With Alcohol Use Disorder.
Red Blood Cell Distribution Width as a Predictor of 28-Day Mortality in Critically Ill Patients With Alcohol Use Disorder.
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红细胞分布宽度作为酒精使用障碍危重患者 28 天死亡率的预测因子。
DOI：
10.1111/acer.14483
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发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Pinhu L
中科院分区：
文献类型：
--
作者：
Liao L;Pinhu L
酒精使用障碍（AUD）患者是重症监护室（ICU）的常见参与者。早期评估重症AUD患者的预后，有利于制定综合治疗措施，提高生存率。本研究旨在探讨红细胞分布宽度（RDW）对AUD危重患者28天死亡率的预测价值。回顾性招募了2，884例AUD患者。收集并分析了MIMIC-III数据库中的数据。采用受试者工作特征（ROC）曲线确定RDW的最佳截止值。采用Kaplan-Meier法和考克斯回归模型分析影响预后的因素。在2，884例患者中，有344例（11.9%）未存活。死亡组RDW高于存活组（p < 0.001）。根据ROC曲线分析，RDW预测28天死亡率的曲线下面积为0.728（95% CI，0.700 - 0.755），最佳临界值为15.45%（灵敏度：67.2%;特异性：67.3%）。RDW > 15.45%患者的ICU住院时间、住院时间、住院死亡率和28天死亡率显著高于RDW ≤ 15.45%的患者（p < 0.001）。考克斯回归分析显示，RDW > 15.45%是AUD重症患者28天死亡率的独立预后指标（HR = 1.964，95% CI：1.429 - 2.698）。高RDW与AUD重症患者的短期死亡风险增加相关。
Patients with alcohol use disorder (AUD) are common attendees of the intensive care unit (ICU). Early assessment of the prognosis for critically ill patients with AUD is conducive for formulating comprehensive treatment measures and improving survival rates. The purpose of this study was to explore the predictive value of red blood cell distribution width (RDW) for 28‐day mortality in critically ill patients with AUD. 2,884 patients with AUD were recruited retrospectively. Data from the MIMIC‐III database were collected and analyzed. A receiver operating characteristic (ROC) curve was used to determine the optimal cutoff value of RDW. The Kaplan–Meier method and Cox regression models were used to evaluate prognostic factors. Of the 2,884 patients, there were 344 nonsurvivors (11.9%). The nonsurvivors had a higher RDW than the survivors (p < 0.001). According to ROC curve analysis, the area under the curve predicted by RDW for 28‐day mortality was 0.728 (95% CI, 0.700 to 0.755) and the optimal cutoff value was 15.45% (sensitivity: 67.2%; specificity: 67.3%). Length of stay in ICU, length of stay in hospital, in‐hospital mortality, and 28‐day mortality in patients with an RDW > 15.45% were significantly higher than in those with an RDW ≤ 15.45% (p < 0.001). Cox regression analysis showed that an RDW > 15.45% was an independent prognostic indicator for 28‐day mortality in critically ill patients with AUD (HR = 1.964, 95% CI: 1.429 to 2.698). High RDW was associated with increased short‐term mortality risks in critically ill patients with AUD.
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影响因子：
4.6
作者：
Jia, Linpei;Cui, Shijun;Zhang, Hongliang
通讯作者：
Zhang, Hongliang
DOI：
10.5492/wjccm.v5.i1.27
发表时间：
2016-02-04
期刊：
World journal of critical care medicine
影响因子：
--
作者：
Mehta, Ashish Jitendra
通讯作者：
Mehta, Ashish Jitendra
影响因子：
8.1
作者：
Walls, Helen;Cook, Sarah;London, Leslie
通讯作者：
London, Leslie
影响因子：
9.8
作者：
Johnson AE;Pollard TJ;Shen L;Lehman LW;Feng M;Ghassemi M;Moody B;Szolovits P;Celi LA;Mark RG
通讯作者：
Mark RG
影响因子：
5.5
作者：
Ansari RA;Husain K;Rizvi SA
通讯作者：
Rizvi SA