Bone reactions to nacre injected percutaneously into the vertebrae of sheep
Bone reactions to nacre injected percutaneously into the vertebrae of sheep
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DOI：
10.1016/s0142-9612(00)00213-1
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发表时间：
2001-03-01
期刊：
影响因子：
14
通讯作者：
Lopez, E
中科院分区：
文献类型：
--
作者：
Lamghari, M;Berland, S;Lopez, E
我们研究了珍珠层（珍珠母）放置在绵羊腰椎制备的实验洞内的成骨作用。一些洞被珍珠层填充，一些洞被PMMA填充，而一些洞被空着。分别于术后1、8、12周取出椎体，进行组织学和形态计量学检查。术后8周，骨腔内及周围小梁间隙的珍珠层颗粒逐渐溶解。在与溶解的珍珠层接触或相邻的不同成熟阶段，有编织的和层状的新形成的骨层。对填充有珍珠质的腔附近的骨形成的活化的定量评估表明骨形成的显著活化，其持续到第12周。此时宿主骨的矿化也增加。在空腔或填充PMMA的空腔中没有新骨形成。PMMA还导致周围骨细胞坏死，骨结构发生变化，骨形成和矿化显著减少。这项研究表明，珍珠层刺激椎骨中的成骨细胞，并似乎导致新骨形成。(C)2001爱思唯尔科技有限公司版权所有。
We have studied the osteogenic effects of nacre (mother of pearl) placed in experimental cavities prepared in the lumbar Vertebrae of sheep. Some of cavities were filled with nacre, some with PMMA, and some were left empty. The Vertebrae were removed 1, 8, 12 weeks after surgery, and assessed histologically and morphometrically. The nacre particles in the bone cavity and the surrounding intertrabecular spaces gradually dissolved beginning at 8 weeks after surgery. There were layers of newly formed bone, both woven and lamellar, in various stages of maturation in contact with or adjacent to the dissolving nacre. Quantitative assessment of the activation of bone formation adjacent to the cavities filled with nacre indicated significant activation of bone formation, which continued until week 12. There was also increased mineralization of the host bone at this time. There was no new bone formation in the empty cavities, or in those filled with PMMA. PMMA also caused necrosis of surrounding bone cells with a change in bone architecture and significant reductions in bone formation and mineralization. This study demonstrates that nacre stimulates bone-forming cells in vertebrae and appears to result in new bone formation. (C) 2001 Elsevier Science Ltd. All rights reserved.