Epidemiology, Clinical Presentation, and Antibody Response to Primary Infection With Herpes Simplex Virus Type 1 and Type 2 in Young Women
Epidemiology, Clinical Presentation, and Antibody Response to Primary Infection With Herpes Simplex Virus Type 1 and Type 2 in Young Women
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DOI：
10.1093/cid/cis891
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发表时间：
2013-02-01
影响因子：
11.8
通讯作者：
Belshe, Robert B.
中科院分区：
文献类型：
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作者：
Bernstein, David I.;Bellamy, Abbie R.;Belshe, Robert B.
背景资料。单纯疱疹病毒1型(HSV-1)和单纯疱疹病毒2型(HSV-2)感染较为常见，但单纯疱疹病毒病的流行病学正在发生变化。在HERPEVAC女性试验的对照组中，年龄18-30岁的HSV血清阴性的妇女被跟踪观察20个月的原发HSV感染。在3438名可评估的参与者中，183人感染了HSV：127人(3.7%)感染了HSV-1，56人(1.6%)感染了HSV-2。HSV-1的感染率(2.5/100人年)是HSV-2(1.1/100人年)的两倍多。大多数感染(74%的HSV-1和63%的HSV-2)发生在没有公认的疱疹疾病体征或症状的情况下。非西班牙裔黑人的HSV-2感染率是西班牙裔的2.6倍，是非西班牙裔白人的5.5倍(P
Background. Herpes simplex virus infections type 1 (HSV-1) and type 2 (HSV-2) are common, but the epidemiology of HSV disease is changing.Methods. HSV-seronegative women, aged 18-30 years, who were in the control arm of the HERPEVAC Trial for Women were followed for 20 months for primary HSV infections.Results. Of the 3438 evaluable participants, 183 became infected with HSV: 127 (3.7%) with HSV-1 and 56 (1.6%) with HSV-2. The rate of infection for HSV-1 (2.5 per 100 person-years) was more than twice that for HSV-2 (1.1 per 100 person-years). Most infections (74% of HSV-1 and 63% of HSV-2) occurred without recognized signs or symptoms of herpes disease. The HSV-2 infection rate was 2.6 times higher in non-Hispanic black participants than in Hispanics and 5.5 times higher than in non-Hispanic whites (P