CLN3P, the Batten disease protein, localizes to membrane lipid rafts (detergent-resistant membranes)
CLN3P, the Batten disease protein, localizes to membrane lipid rafts (detergent-resistant membranes)
复制标题
DOI：
10.1016/j.bbrc.2004.03.146
复制
发表时间：
2004-05-14
影响因子：
3.1
通讯作者：
Bennett, MJ
中科院分区：
文献类型：
--
作者：
Rakheja, D;Narayan, SB;Bennett, MJ
青少年神经元蜡样质脂褐质沉积症是一种遗传性儿科神经退行性疾病，其发生是由于位于染色体16p 12.1上的CLN3基因突变。编码的蛋白CLN3P是一种功能未知的跨膜蛋白。在这项研究中，我们表明，CLN3P驻留在膜脂筏结构域（耐洗涤剂膜），并提供重要的新数据对蛋白质的可能功能。(C)2004爱思唯尔公司All rights reserved.
Juvenile neuronal ceroid lipofuscinosis is an inherited pediatric neurodegenerative disorder, which occurs as a result of mutations in the CLN3 gene that is located on chromosome 16p 12.1. The encoded protein, CLN3P, is a putative transmembrane protein with no known function. In this study, we demonstrate that CLN3P resides on membrane lipid raft domains (detergent-resistant membranes) and provide important new data towards possible functions of the protein. (C) 2004 Elsevier Inc. All rights reserved.