Mood improvement following daily left prefrontal repetitive transcranial magnetic stimulation in patients with depression: A placebo-controlled crossover trial
Mood improvement following daily left prefrontal repetitive transcranial magnetic stimulation in patients with depression: A placebo-controlled crossover trial
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DOI：
10.1176/ajp.154.12.1752
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发表时间：
1997-12-01
影响因子：
17.7
通讯作者：
Post, RM
中科院分区：
文献类型：
--
作者：
George, MS;Wassermann, EM;Post, RM
目的：初步研究表明，每日左前额重复经颅磁刺激可能具有抗抑郁活性。作者试图通过使用双盲交叉设计来证实这一发现。方法：12名抑郁症成年人随机接受2周的积极治疗（重复经颅磁刺激，20 Hz，80%运动阈值）和2周的假治疗。结果如下：21项汉密尔顿抑郁量表评分相对于相关阶段基线的变化表明，重复经颅磁刺激与假治疗相比显著改善了情绪。在积极治疗阶段，汉密尔顿抑郁量表评分下降5分，而在假治疗期间，评分增加或恶化3分。未观察到不良反应。结论：这些安慰剂对照结果表明，每日左前额重复经颅磁刺激具有抗抑郁活性时，在这些参数。进一步的对照研究表明，探索最佳的刺激特性和位置，潜在的临床应用，和可能的作用机制。
Objective: Preliminary studies have indicated that daily left prefrontal repetitive transcranial magnetic stimulation might have antidepressant activity. The authors sought to confirm this finding by using a double-blind crossover design. Method: Twelve depressed adults received in random order 2 weeks of active treatment (repetitive transcranial magnetic stimulation, 20 Hz at 80% motor threshold) and 2 weeks of sham treatment. Results: Changes from the relevant phase baseline in scores on the 21-item Hamilton depression scale showed that repetitive transcranial magnetic stimulation significantly improved mood over sham treatment. During the active-treatment phase, Hamilton depression scale scores decreased 5 points, while during sham treatment the scores increased or worsened by 3 points. No adverse effects were noted. Conclusions: These placebo-controlled results suggest that daily left prefrontal repetitive transcranial magnetic stimulation has antidepressant activity when administered at these parameters. Further controlled studies are indicated to explore optimal stimulation characteristics and location, potential clinical applications, and possible mechanisms of action.