AMPA receptor trafficking in the dorsal striatum is critical for behavioral sensitization to cocaine in juvenile mice
AMPA receptor trafficking in the dorsal striatum is critical for behavioral sensitization to cocaine in juvenile mice
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DOI：
10.1016/j.bbrc.2008.12.003
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发表时间：
2009-01-30
影响因子：
3.1
通讯作者：
Yoon, Bong-June
中科院分区：
文献类型：
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作者：
Kim, Myonghwan;Au, Eunkyu;Yoon, Bong-June
对成瘾神经生物学的研究进展表明，中边缘系统中不仅有多巴胺能神经递质，还有谷氨酸能神经递质也起着重要的作用。虽然伏隔核（NAc）壳核在成瘾中的作用已被广泛研究，但背纹状体的功能尚不清楚。在这里，我们证明反复注射可卡因导致背纹状体中不良表面表达的AMPA受体增加。AMPAR在幼龄小鼠中的表达比患病的幼龄成年小鼠更为强烈。此外，G1CT肽的表达可以阻止AMPARs传递到表面，从而减弱幼年小鼠的运动致敏性。我们的研究结果强烈表明，背纹状体的谷氨酸能突触可塑性可能在可卡因行为致敏中起重要作用，并且可能存在不同的年龄依赖的控制机制。(C) 2008爱思唯尔公司版权所有。
Advances in understanding the neurobiology of addiction indicate that not only dopaminergic neurotransmissions but also glutamatergic neurotransmissions within the mesolimbic system play important roles. While the role for the nucleus accumbens (NAc) shell and core in addiction has been extensively studied, the function of the dorsal striatum is not clear. Here, we demonstrate that repeated cocaine injections cause increases ill surface-expressed AMPA receptors in the dorsal striatum. The increased AMPAR expression is more robust in juvenile mice than ill Young adult mice. Furthermore, expression of the G1CT peptide, which prevents the delivery of AMPARs to the surface, attenuates the locomotor sensitization in juvenile mice. Our results strongly suggest that glutamatergic synaptic plasticity in the dorsal striatum may have an important role in behavioral sensitization to cocaine and that there may be different age-dependent control mechanisms. (C) 2008 Elsevier Inc. All rights reserved.