Chemically targeting the PI3K family
Chemically targeting the PI3K family
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DOI：
10.1042/bst0350245
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发表时间：
2007-04-01
影响因子：
3.9
通讯作者：
Shokat, K. M.
中科院分区：
文献类型：
--
作者：
Knight, Z. A.;Shokat, K. M.
PI 3 K（phosphoinositide 3-kinase）是细胞生长、代谢和存活的关键调节因子。癌症中PI 3 K通路的频繁激活激发了人们对鉴定PI 3 K亚型的有效和选择性抑制剂的广泛兴趣。本文重点介绍了最近在识别这些分子方面的进展，以及针对PI 3 K家族的靶向研究所面临的挑战。
PI3K (phosphoinositide 3-kinase) is a key regulator of cell growth, metabolism and survival. The frequent activation of the PI3K pathway in cancer has stimulated widespread interest in identifying potent and selective inhibitors of PI3K isoforms. The present paper highlights recent progress in identifying such molecules and the challenges that remain for efforts to pharmacologically target the PI3K family.