Autologous stem cell transplantation for treatment of rectovaginal fistula in perianal Crohn's disease:: a new cell-based therapy
Autologous stem cell transplantation for treatment of rectovaginal fistula in perianal Crohn's disease:: a new cell-based therapy
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DOI：
10.1007/s00384-003-0490-3
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发表时间：
2003-09-01
影响因子：
2.8
通讯作者：
García-Sancho, L
中科院分区：
文献类型：
--
作者：
García-Olmo, D;García-Arranz, M;García-Sancho, L
背景和目的：克罗恩病患者的直肠阴道瘘很难解决，手术失败是很常见的。最近的研究表明，从某些组织（如脂肪组织）中提取的成体干细胞可以发育成不同的组织，如肌肉。患者和方法：我们在这里报告的情况下，与克罗恩病的年轻患者谁有复发性直肠阴道瘘治疗自体干细胞移植与脂肪抽吸物作为干细胞的来源。结果：虽然克罗恩病是直肠阴道瘘手术入路的最差情况，但我们观察到良好的闭合。自3个月前的外科手术以来，患者未经历阴道排气或经阴道大便失禁。因此，我们的治疗似乎有效。结论：细胞移植来克服愈合问题是一种新的手术工具，仔细评估这种新的方式可能会提供一个机会，以定义一个新的时代，在治疗与愈合障碍相关的手术挑战。伦理和安全项目似乎并不是使用自体干细胞的关键问题。
Background and aims: Rectovaginal fistulas in patients with Crohn's disease are difficult to resolve, and surgical failure is very frequent. Recent studies have shown that adult stem cells extracted from certain tissues, such as adipose tissue, can develop into different tissues, such as muscle. Patient and methods: We report here the case of a young patient with Crohn's disease who had a recurrent rectovaginal fistula that was treated by autologous stem-cell transplantation with a lipoaspirate as the source of stem cells. Results: Although Crohn's disease is the worst condition for a surgical approach in cases of rectovaginal fistula, we observed good closure. Since the surgical procedure 3 month ago the patient has not experienced vaginal flatus or fecal incontinence through her vagina. Thus our treatment seems to be effective. Conclusion: Cell transplantation to overcome healing problems is a new surgical tool, and careful evaluation of this new modality may provide an opportunity to define a new era in the treatment of surgical challenges associated with healing disorders. Ethical and safety items do not seem to be critical problems using autologous stem cells.