Frontostriatal circuits, resting state functional connectivity and cognitive control in internet gaming disorder.
Frontostriatal circuits, resting state functional connectivity and cognitive control in internet gaming disorder.
复制标题
网络游戏障碍中的额纹状体回路、静息态功能连接和认知控制
DOI：
10.1111/adb.12348
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发表时间：
2017
影响因子：
3.4
通讯作者：
Tian Jie
中科院分区：
文献类型：
--
作者：
Yuan Kai;Yu Dahua;Cai Chenxi;Feng Dan;Li Yangding;Bi Yanzhi;Liu Jixin;Zhang Yi;Jin Chenwang;Li Linling;Qin Wei;Tian Jie
越来越多的证据表明，互联网游戏障碍(IGD)存在认知控制缺陷。最近，越来越多的证据表明，静息状态的功能连接(RSFC)和额纹状体回路的结构连接可以调节健康个体的认知控制。不幸的是，关于静息状态下额纹状体通路(包括背侧和腹侧纹状体)的完整回路水平特征以及它们与IGD认知控制的关联，人们知之甚少。在本研究中，我们调查了43名年轻IGD患者和44名健康对照的纹状体体积和RSFC网络的差异。同时，采用Stroop作业成绩评定认知控制缺陷。然后，将神经成像结果与Stroop任务行为相关联。在IGD受试者中，我们发现右侧尾状核和伏隔核(NAC)的体积增加，而背侧前额叶皮质(DLPFC)尾状核和眶前额叶皮质(OFC)NAC的RSFC强度降低。IGD患者的NAC容量与网络成瘾测试成绩呈正相关。IGD患者的尾状核体积和DLPFC-尾状核RSFC与认知控制受损(Stroop任务中的不协调错误较多)相关。与物质使用障碍(SUD)的结果一致，我们检测了IGD和健康对照组的纹状体体积和额纹状体回路RSFC的差异，这为IGD和SUD之间提供了一定程度的相似性的证据。更重要的是，IGD患者的认知控制缺陷与额叶顶叶RSFC强度降低相关。希望我们的结果能够深入了解IGD的神经生物学机制，并为治疗提供潜在的新治疗靶点。
Converging evidence has identified cognitive control deficits in internet gaming disorder (IGD). Recently, mounting evidence had revealed that resting state functional connectivity (RSFC) and structural connectivity of frontostriatal circuits could modulate cognitive control in healthy individuals. Unfortunately, relatively little is known about the thoroughly circuit‐level characterization of the frontostriatal pathways (both the dorsal and ventral striatum) during resting‐state and their association with cognitive control in IGD. In the current study, the differences of striatum volume and RSFC networks were investigated between 43 young IGD individuals and 44 healthy controls. Meanwhile, cognitive control deficits were assessed by Stroop task performances. The neuroimaging findings were then correlated with the Stroop task behaviors. In IGD subjects, we demonstrated an increased volume of right caudate and nucleus accumbens (NAc) as well as reduced RSFC strength of dorsal prefrontal cortex (DLPFC)–caudate and orbitofrontal cortex (OFC)–NAc. NAc volumes were positively correlated with internet addiction test scores in IGD. The caudate volume and DLPFC–caudate RSFC was correlated with the impaired cognitive control (more incongruent errors in Stroop task) in IGD. Consistent with substance use disorder (SUD) findings, we detected striatum volume and frontostriatal circuits RSFC differences between IGD and healthy controls, which provided evidence of some degree of the similarity between IGD and SUD. More importantly, the cognitive control deficits in IGD were correlated with the reduced frontostrital RSFC strength. It is hoped that our results could shed insight on the neurobiological mechanisms of IGD and suggest potential novel therapeutic targets for treatment.