The temporal dynamics of insula activity to disgust and happy facial expressions: A magnetoencephalography study
The temporal dynamics of insula activity to disgust and happy facial expressions: A magnetoencephalography study
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DOI：
10.1016/j.neuroimage.2009.04.093
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发表时间：
2009-10-01
期刊：
影响因子：
5.7
通讯作者：
Mathiak, Klaus
中科院分区：
文献类型：
--
作者：
Chen, Yu-Han;Dammers, Juergen;Mathiak, Klaus
一直以来，研究人员都发现，丘脑参与处理引起厌恶情绪反应的刺激。最近，其处理厌恶的特异性受到了挑战，并建议在内感受信息的表征中发挥更广泛的作用。研究情绪处理过程中的脑激活的时间动态可以为这个问题提供有价值的信息。很少有研究涉及到恶心的假定特异性及其潜在神经过程的动力学。在本研究中，神经磁反应的13名受试者执行情绪连续执行任务（CPT）的面孔厌恶，高兴，和中性的表情。磁场断层扫描提取了双侧脑电活动的时间过程。在刺激开始后约200 ms，右侧的刺激对厌恶和快乐的激活比中性面部表情更强。后来，只有在刺激开始后约350毫秒，右颞叶被激活更强的厌恶比快乐的面部表情。因此，早期的右丘脑反应反映了对情绪激发刺激的激活，而不管效价如何，晚期的右丘脑反应区分了厌恶和快乐的面部表情。行为表现，但不是神经活动不同之间的100毫秒和1000毫秒的介绍条件。目前的研究结果支持这一概念，即大脑皮层参与内感受信息的表征。(C)2009 Elsevier Inc. All rights reserved.
The insula has consistently been shown to be involved in processing stimuli that evoke the emotional response of disgust. Recently, its specificity for processing disgust has been challenged and a broader role of the insula in the representation of interoceptive information has been suggested. Studying the temporal dynamics of insula activation during emotional processing can contribute valuable information pertaining to this issue. Few studies have addressed the insula's putative specificity to disgust and the dynamics of its underlying neural processes. In the present study, neuromagnetic responses of 13 subjects performing an emotional continuous performance task (CPT) to faces with disgust, happy, and neutral expressions were obtained. Magnetic field tomography extracted the time course of bilateral insula activities. Right insula activation was stronger to disgust and happy than neutral facial expressions at about 200 ms after stimulus onset. Later only at about 350 ms after stimulus onset the right insula was activated stronger to disgust than happy facial expressions. Thus, the early right insula response reflects activation to emotionally arousing stimuli regardless of valence, and the later right insula response differentiates disgust from happy facial expressions. Behavioral performance but not the insula activity differed between 100 ms and 1000 ms presentation conditions. Present findings support the notion that the insula is involved in the representation of interoceptive information. (C) 2009 Elsevier Inc. All rights reserved.