MAPPING THE COCHLEAR PARTITIONS STIFFNESS TO ITS CELLULAR ARCHITECTURE
MAPPING THE COCHLEAR PARTITIONS STIFFNESS TO ITS CELLULAR ARCHITECTURE
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DOI：
10.1121/1.408331
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发表时间：
1994-01-01
影响因子：
2.4
通讯作者：
MOUNTAIN, DC
中科院分区：
文献类型：
--
作者：
OLSON, ES;MOUNTAIN, DC
耳蜗分区的机械特性是听觉传导的基础。我们测量了点刚度的分区，在体内，在多达17个径向位置跨越其宽度，在基底转的沙鼠耳蜗。我们发现，在梳状带中，最有可能在外柱细胞下的位置处的线性刚度比朝向韧带的相邻位置大1.5倍，并且比朝向椎板的相邻位置大5倍，在弓状带中。这种径向变化似乎反映了分区的细胞几何形状：柱细胞定位为结构元素，基底膜支持梳状区中丰富的细胞结构，而它与弓形区中充满液体的空间接壤。我们发现，隔板刚度的径向变化将影响被动耳蜗力学，并且也与主动耳蜗力学有关，因为它支持细胞作为有效力发生器的可扩展性。我们的结果，从测量在体内延伸的结果，以前的测量结果在切除耳蜗，其中细胞的贡献刚度是不太明显。
The mechanical properties of the cochlear partition are fundamental to auditory transduction. We measured the point stiffness of the partition, in vivo, at up to 17 radial positions spanning its width, in the basal turn of the gerbil cochlea. We found the linear stiffness at the position that is most likely under the outer pillar cells to be 1.5 times greater than adjacent positions toward the ligament, in the pectinate zone, and five times greater than adjacent positions toward the lamina, in the arcuate zone. This radial variation seems to reflect the cellular geometry of the partition: The pillar cell is positioned as a structural element, and the basilar membrane supports a rich cellular structure in the pectinate zone, whereas it borders a fluid-filled space in the arcuate zone. The radial variation in partition stiffness we find will influence passive cochlear mechanics, and also bears on active cochlear mechanics, since it supports the plausibility of cells as effective force generators. Our results from measurements made in vivo extend the findings of previous measurements made in excised cochleae, in which the cellular contribution to stiffness was less evident.