Movement Initiation-Locked Activity of the Anterior Putamen Predicts Future Movement Instability in Periodic Bimanual Movement
Movement Initiation-Locked Activity of the Anterior Putamen Predicts Future Movement Instability in Periodic Bimanual Movement
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DOI：
10.1523/jneurosci.4473-10.2011
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发表时间：
2011-07-06
影响因子：
5.3
通讯作者：
Sadato, Norihiro
中科院分区：
文献类型：
--
作者：
Aramaki, Yu;Haruno, Masahiko;Sadato, Norihiro
在周期性的双手运动中，反相协调模式经常突然不由自主地转变为同相模式。由于周期序列初期的行为通常不会显示出任何明显的误差，因此很难预测周期序列后期的后续运动误差。在这里，我们使用功能磁共振成像测量的人脑活动以及使用初始运动特征来评估双手周期性运动周期序列的后期表现。18名受试者完成了30名S的双手手指敲击任务。我们计算了反相敲击和同相敲击条件下启动锁定的瞬时脑活动的差异。相关分析表明，反相与同相敲击条件下的前壳核活动的差异与未来的不稳定性有很强的相关性，用反相运动期间左手敲击间期相对于同相运动的平均绝对偏差来衡量(r=0.81)。在我们测量的初始运动特征中，只有建立反相运动模式的敲击次数显示出显著的相关性。然而，0.60的相关系数不足以预测后续运动的特征。壳核活性与初始运动特征之间无显著相关性。启动不熟练的困难动作可能需要增加前壳核的活动，这种活动的增加可能有助于通过基底节-丘脑皮质环路启动运动。我们的结果表明，前壳核的起始锁定的瞬时活动可以用来预测未来的运动表现。
In periodic bimanual movements, anti-phase-coordinated patterns often change into in-phase patterns suddenly and involuntarily. Because behavior in the initial period of a sequence of cycles often does not show any obvious errors, it is difficult to predict subsequent movement errors in the later period of the cyclical sequence. Here, we evaluated performance in the later period of the cyclical sequence of bimanual periodic movements using human brain activity measured with functional magnetic resonance imaging as well as using initial movement features. Eighteen subjects performed a 30 s bimanual finger-tapping task. We calculated differences in initiation-locked transient brain activity between antiphase and in-phase tapping conditions. Correlation analysis revealed that the difference in the anterior putamen activity during antiphase compared within-phase tapping conditions was strongly correlated with future instability as measured by the mean absolute deviation of the left-hand intertap interval during antiphase movements relative to in-phase movements (r = 0.81). Among the initial movement features we measured, only the number of taps to establish the antiphase movement pattern exhibited a significant correlation. However, the correlation efficient of 0.60 was not high enough to predict the characteristics of subsequent movement. There was no significant correlation between putamen activity and initial movement features. It is likely that initiating unskilled difficult movements requires increased anterior putamen activity, and this activity increase may facilitate the initiation of movement via the basal ganglia-thalamocortical circuit. Our results suggest that initiation-locked transient activity of the anterior putamen can be used to predict future motor performance.