Determinants of reflux-induced chronic cough
Determinants of reflux-induced chronic cough
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DOI：
10.1136/gutjnl-2017-313721
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发表时间：
2017-12-01
期刊：
影响因子：
24.5
通讯作者：
Smout, Andre J. P. M.
中科院分区：
文献类型：
--
作者：
Herregods, Thomas V. K.;Pauwels, Ans;Smout, Andre J. P. M.
目的胃食道反流被认为是慢性不明原因咳嗽的重要致病因素。目前尚不清楚为什么同一患者的一些反流发作会导致咳嗽，而另一些则不会。为了更多地了解反流引起咳嗽的机制，我们的目的是找出触发咳嗽的重要因素。在这项多中心研究中，对49例反流相关的慢性咳嗽患者进行24小时pH-阻抗-压力监测。结果72.4%(72.4%)的反流性发作为酸性(pH
Objective Gastro-oesophageal reflux is considered to be an important contributing factor in chronic unexplained cough. It remains unclear why some reflux episodes in the same patient causes cough while others do not. To understand more about the mechanism by which reflux induces cough, we aimed to identify factors which are important in triggering cough.Design In this multicentre study, 49 patients with reflux-associated chronic cough were analysed using 24-hour pH-impedance-pressure monitoring. The characteristics of reflux episodes that were followed by cough were compared with reflux episodes not associated with cough.Results The majority (72.4%) of the reflux episodes were acidic (pH