Cannabis use in people with severe mental illness: The association with physical and mental health - a cohort study. A Pharmacotherapy Monitoring and Outcome Survey study
Cannabis use in people with severe mental illness: The association with physical and mental health - a cohort study. A Pharmacotherapy Monitoring and Outcome Survey study
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DOI：
10.1177/0269881116631652
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发表时间：
2016-04-01
影响因子：
4.1
通讯作者：
Jorg, Frederike
中科院分区：
文献类型：
--
作者：
Bruins, Jojanneke;Pijnenborg, Marieke G. H. M.;Jorg, Frederike
目的：在普通人群中，大麻的使用与更好的心脏代谢结果相关。患有严重精神疾病的患者经常使用大麻，但也存在心脏代谢风险增加的因素。我们探讨了严重精神疾病患者中大麻使用与心脏代谢危险因素之间的关系。方法：来自荷兰队列的3169名严重精神疾病患者被纳入研究。用独立的单变量AN(C)OVA检验大麻使用与体重指数、腰围、血压、胆固醇、甘油三酯、血糖、糖化血红蛋白以及阳性和阴性综合征评分的关系。结果：基线吸食大麻患者的体重指数、腰围较小，舒张压较低，精神症状较重。首次评估后停用大麻的患者的体重指数、腰围、舒张压和甘油三酯浓度较其他患者有较大幅度的增加，其精神症状的严重程度比继续吸食和不使用大麻的患者下降得更多。结论：应特别关注停用大麻患者的代谢参数的监测和治疗。
Objective: In the general population cannabis use is associated with better cardiometabolic outcomes. Patients with severe mental illness frequently use cannabis, but also present increased cardiometabolic risk factors. We explore the association between cannabis use and cardiometabolic risk factors in patients with severe mental illness.Method: A total of 3169 patients with severe mental illness from a Dutch cohort were included in the study. The association of cannabis use with body mass index, waist circumference, blood pressure, cholesterol, triglycerides, glucose, glycated hemoglobin and Positive and Negative Syndrome Scale was examined with separate univariate AN(C)OVA. Changes in metabolic risk factors and Positive and Negative Syndrome Scale were examined after a follow-up interval of 9-24 months, for patients who continued, discontinued, started or were never using cannabis between the two assessments.Results: Cannabis users at baseline had lower body mass index, smaller waist circumference, lower diastolic blood pressure, and more severe psychotic symptoms than non-users. Patients who discontinued their cannabis use after the first assessment had a greater increase in body mass index, waist circumference, diastolic blood pressure and triglyceride concentrations than other patients, and the severity of their psychotic symptoms had decreased more compared to continued users and non-users.Conclusion: Extra attention should be paid to the monitoring and treatment of metabolic parameters in patients who discontinue their cannabis use.