Rat plasma α1‐inhibitor3: a member of the α‐macroglobulin family
Rat plasma α1‐inhibitor3: a member of the α‐macroglobulin family
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大鼠血浆 α1-抑制剂 3：α-巨球蛋白家族的成员
DOI：
10.1016/0014-5793(85)81168-6
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发表时间：
1985
期刊：
影响因子：
3.5
通讯作者：
F. Gauthier
中科院分区：
文献类型：
--
作者：
F. Esnard;N. Gutman;A. el Moujahed;F. Gauthier
α- 1抑制剂（一种血浆蛋白酶抑制剂）与蛋白酶相互作用的总体机制与α-巨球蛋白的相互作用非常相似。该机制包括：(i)至少一个易感肽键的断裂导致分子的结构变化，（ii）分子另一位点假定的硫醇酯键的断裂允许酶的共价键。此外，α-巨球蛋白四分之一亚基的α- 1抑制剂在加热时也会断裂。问题是，除了两种α-巨球蛋白外，在大鼠血浆中还存在这样一种分子，所有这些蛋白酶抑制剂在抗原性上是不相关的。-巨球蛋白大鼠血浆硫醇酯
The overall mechanism of interaction with proteinases of α1-inhibitor3, a plasma proteinase inhibitor so far specific to the rat, has been shown to be closely similar to that described for α-macroglobulins. This mechanism includes: (i) the cleavage of at least one susceptible peptidic bond which leads to structural changes in the molecule, (ii) The cleavage of a putative thiol ester bond in another site of the molecule which permits the covalent linkage of the enzyme. Moreover, fragmentation of α1-inhibitor3upon heating as observed for α-macroglobulin quarter subunits has been demonstrated. The question is raised of the presence of such a molecule in rat plasma in addition to two α-macroglobulin species, all of these proteinase inhibitors being antigenically unrelated.α1Inhibitor3α.-MacroglobulinRat plasmaThiol esterHeat fragmentation