Genetics of hypertension and cardiovascular disease and their interconnected pathways: lessons from large studies.
Genetics of hypertension and cardiovascular disease and their interconnected pathways: lessons from large studies.
复制标题
高血压和心血管疾病的遗传学及其相互联系的途径：大型研究的教训。
DOI：
10.1007/s11906-010-0174-7
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发表时间：
2011-02
影响因子：
5.6
通讯作者：
Province, Michael A.
中科院分区：
文献类型：
--
作者：
Kraja, Aldi T.;Hunt, Steven C.;Rao, D. C.;Davila-Roman, Victor G.;Arnett, Donna K.;Province, Michael A.
关键词：
血压（BP）、高血压（HT）和心血管疾病（CVD）是常见的复杂表型，受多种遗传和环境因素的影响。本文描述了最近的全基因组关联研究（GWAS），这些研究报告了BP/HT和CVD/心脏特征的致病变异，并分析了重叠的相关基因多态性。它还研究了HyperGEN数据对非裔美国人和白人的研究结果的潜在复制。一些参与血压/高温调节的基因似乎也参与心血管疾病。一个更好的图景正在出现，热点区域重叠，BP/HT和CVD之间的通路相互连接。全面了解BP/HT和CVD的发展及其疾病进展的系统方法可能有助于确定基因靶点和开发新的治疗干预措施的途径。
Blood pressure (BP), hypertension (HT) and cardiovascular disease (CVD) are common complex phenotypes, which are affected by multiple genetic and environmental factors. This article describes recent genome-wide association studies (GWAS) that have reported causative variants for BP/HT and CVD/heart traits and analyzes the overlapping associated gene polymorphisms. It also examines potential replication of findings from the HyperGEN data on African Americans and whites. Several genes involved in BP/HT regulation also appear to be involved in CVD. A better picture is emerging, with overlapping hot-spot regions and with interconnected pathways between BP/HT and CVD. A systemic approach to full understanding of BP/HT and CVD development and their progression to disease may lead to the identification of gene targets and pathways for the development of novel therapeutic interventions.
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