THE IMPORTANCE OF IMPORTIN
THE IMPORTANCE OF IMPORTIN
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DOI：
10.1016/s0962-8924(00)88991-6
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发表时间：
1995-05-01
影响因子：
19
通讯作者：
ADAM, SA
中科院分区：
文献类型：
--
作者：
ADAM, SA
嗜钾蛋白在细胞核中的积累需要细胞质因子。重建核蛋白输入的无细胞系统已被用于鉴定这些因素中的几个，并确定输入过程的生化要求。最近，从非洲爪蟾中纯化并克隆了一种因子，并鉴定为最初在酵母中描述的“RNA聚合酶抑制因子I”（SRP1）基因的同源物。该因子属于一组密切相关的蛋白质，可能在核蛋白质转运中具有相似的功能。
The accumulation of kalyophilic proteins in the nucleus requires cytoplasmic factors. Cell-free systems that reconstitute nuclear protein import have been used to identify, several of these factors and to define the biochemical requirements for the import process. Recently, one factor has been purified and cloned from Xenopus and identified as a homologue of the 'suppressor of RNA polymerase I' (SRP1) gene originally described in yeast. This factor belongs to a closely related group of proteins that may share similar functions in nuclear protein transport.