EPILEPSY IN A POPULATION OF 6000 REEXAMINED - SECULAR TRENDS IN FIRST ATTENDANCE RATES, PREVALENCE, AND PROGNOSIS
EPILEPSY IN A POPULATION OF 6000 REEXAMINED - SECULAR TRENDS IN FIRST ATTENDANCE RATES, PREVALENCE, AND PROGNOSIS
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DOI：
10.1136/jnnp.58.5.570
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发表时间：
1995-05-01
影响因子：
11
通讯作者：
SHORVON, SD
中科院分区：
文献类型：
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作者：
COCKERELL, OC;ECKLE, I;SHORVON, SD
重要的是记录一般人群中癫痫的生命统计数据的变化，以便能够评估预防和治疗的成功或失败，并规划卫生措施。对6000人进行了间隔10年的研究，以确定癫痫患病率和预后的长期趋势。所有患者一生中有一次或多次发热性癫痫发作的发生率在1983年为20.3/1000 (95% CI 16.9-24.3)， 1993年为21.1 /1000 （95% CI 17.6-25.1）。活动性癫痫的患病率1983年为5.3/1000 (95% CI 3.6-7.5)， 1993年为4.3 （95% CI 2.8-6.3）。为了评估发病率的趋势，从1964年到1993年测量了每年的首次出勤率。儿童（年龄< 20岁）的年首次就诊率从1974-83年的152.4/10万（90% CI 106.0-212.9）下降到1984-93年的60.9/10万（90% CI 33.0-103.3），表明儿童癫痫发病率正在下降。同样值得注意的是，1984-93年老年人（61-80岁）癫痫的首次就诊率为82.0 (90% CI 38.5-154.0)，高于任何其他年龄组。老年癫痫患者人数的增加很重要，并对健康规划产生影响，特别是随着老年人口总数的总体增加。然而，没有证据表明预后在过去40年中有明显改变。
It is important to document changes in the vital statistics of epilepsy in the general population so that the success or failure of prevention and treatment can be assessed and health provisions planned. A population of 6000 persons was studied 10 years apart to determine secular trends in the prevalence and prognosis of epilepsy. The lifetime prevalence of all patients with one or more afebrile seizures was 20.3/1000 (95% CI 16.9-24.3) in 1983 and 21.0/1000 (95% CI 17.6-25.1) in 1993. The prevalence of active epilepsy was 5.3/1000 (95% CI 3.6-7.5) in 1983 and 4.3 (95% CI 2.8-6.3) in 1993. To assess trends in incidence rates the annual first attendance rates were measured from 1964 to 1993. Annual first attendance rates in children (age < 20 years) have declined from 152.4/100 000 (90% CI 106.0-212.9) in the years 1974-83, to 60.9/100 000 (90% CI 33.0-103.3) in the years from 1984-93, suggesting that the incidence of epilepsy in children is falling, Also noteworthy was the first attendance rates for epilepsy in elderly people (61-80 years) in the years 1984-93, of 82.0 (90% CI 38.5-154.0), higher than in any other age group. This increase in the number of elderly patients with epilepsy is important, and has health planning implications, especially with the overall increase in the total elderly population. There was, however, no evidence that prognosis has significantly altered in the past 40 years.