A novel marker in pregnant with preeclampsia: renalase
A novel marker in pregnant with preeclampsia: renalase
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DOI：
10.1080/14767058.2016.1186637
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发表时间：
2017-04-01
影响因子：
1.8
通讯作者：
Erdem, Yunus
中科院分区：
文献类型：
--
作者：
Yilmaz, Zehra Vural;Akkas, Elif;Erdem, Yunus
背景：子痫前期以高血压升高、GFR和蛋白尿降低为特征，但其潜在机制尚不清楚。Renalase是最近发现的一种与人类血压调节有关的蛋白质。材料与方法：测定妊娠晚期健康对照、健康孕妇和符合年龄、胎龄的子痫前期孕妇血清renalase血药浓度。血清renalase水平在有和没有先兆子痫的孕妇和未怀孕的对照组进行比较。与妊娠期血清renalase水平相关的因素也被评估。结果：健康孕妇血清renalase水平明显高于对照组。然而，患有先兆子痫的孕妇的renalase水平低于健康对照组。血清renalase水平与血压水平呈负相关，与肾小球滤过率呈正相关。结论：妊娠期子痫前期的发生伴有血清renalase水平的改变。高血压和肾损害是这种疾病的特征，至少部分是由低再酶水平介导的。
Background: Preeclampsia is characterized by an increase in high blood pressure and decrease in GFR and proteinuria, however, the underlying mechanisms are still unclear. Renalase is a recently discovered protein implicated in regulation of blood pressure in humans.Materials and methods: Plasma concentrations of serum renalase were measured in healthy controls, healthy pregnant and pregnant with preeclampsia matched for age, gestational age, in the third trimester of pregnancy. Serum renalase levels were compared in pregnant with and without preeclampsia and non-pregnant controls. Factors associated with serum renalase levels in pregnancies were also evaluated.Results: In healthy pregnant serum renalase levels were significantly higher than in controls. However, pregnant with preeclampsia had lower renalase levels than healthy controls. Serum renalase levels were inversely associated with blood pressure levels and positively correlated with glomerular filtration rate.Conclusion: The results indicated that the development of preeclampsia in pregnant is accompanied by altered serum renalase levels. High blood pressure and kidney damage that characterize this disorder are mediated at least in part by low renalase levels.