Effects of cocaine and d-amphetamine on behavior maintained under various schedules of food presentation in squirrel monkeys.
Effects of cocaine and d-amphetamine on behavior maintained under various schedules of food presentation in squirrel monkeys.
复制标题
可卡因和 d-苯丙胺对松鼠猴在不同食物呈现时间表下维持的行为的影响。
DOI：
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发表时间：
1977
影响因子：
3.5
通讯作者：
S. Goldberg
中科院分区：
文献类型：
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作者：
F. Gonzalez;S. Goldberg
确定了可卡因和 d-苯丙胺对在三种食物呈现方案下维持的杠杆按压反应的影响的剂量反应函数：1）简单的固定比例方案，2）多个固定比例、固定间隔方案和 3）具有固定比例成分的二阶固定间隔方案。这些时间表产生了各种响应率和模式。药物对反应率的影响取决于反应的控制率。在固定比例计划和多重计划的固定比例部分下，总体响应率保持最高。可卡因和 d-苯丙胺都会导致这些高反应率出现剂量相关的下降。在二阶计划和多重计划的固定间隔部分下，总体响应率保持较低。中等剂量的可卡因或 d-苯丙胺 (0.1-1.0 mg/kg) 增加了这些较低的反应率。在二阶时间表和多重时间表下，固定间隔的连续片段期间的局部反应率受到药物的不同影响。可卡因和 d-苯丙胺显着增加了固定间隔初始阶段发生的低反应率，但对固定间隔后期阶段发生的较高反应率几乎没有影响或降低。可卡因和 d-安非他明对反应的定性和定量影响相似，但 d-安非他明比可卡因更持久。
Dose-response functions were determined for the effects of cocaine and d-amphetamine on lever-pressing responses maintained under three schedules of food presentation: 1) a simple fixed-ratio schedule, 2) a multiple fixed-ratio, fixed-interval schedule and 3) a second-order fixed-interval schedule with fixed-ratio components. These schedules generated a variety of rates and patterns of responding. The effects of the drugs on response rate depended on the control rates of responding. The highest overall rates of responding were maintained under the fixed-ratio schedule and under the fixed-ratio component of the multiple schedule. Both cocaine and d-amphetamine produced dose-related decreases in these high response rates. Lower overall rates of responding were maintained under the second-order schedule and under the fixed-interval component of the multiple schedule. Intermediate doses of cocaine or d-amphetamine (0.1-1.0 mg/kg) increased these lower rates of responding. Under the second-order schedule and the multiple schedule, local response rates during successive segments of the fixed-intervals were differentially affected by the drugs. Cocaine and d-amphetamine markedly increased low response rates that occurred during initial segments of the fixed intervals, but either had little effect on or decreased higher responses rates that occurred during later segments of the fixed intervals. Cocaine and d-amphetamine had similar qualitative and quantitative effects on responding, but d-amphetamine was longer lasting than cocaine.